The human coagulation protease factor VII plays a pivotal role in the initiation of the
coagulation cascade by both the extrinsic and the intrinsic pathway. Although the gene …

Promoter and silencer elements of the immediate 5'flanking region of the gene coding for
human factor VII were identified and characterized. The major transcription start site …

To identify the 5′ sequences of the murine coagulation factor VII (fVII) gene that resulted in
its efficient transcription, a variety of 5′-flanking sequences up to 7 kilobase pairs upstream …

Hepatocyte nuclear factor 4α (HNF4α) plays an important role in the maintenance of many
liver-specific functions. Liver-specific HNF4α-null mice were used to determine whether …

The gene encoding murine coagulation factor VII (fVII) has been cloned. Seven introns and
eight exons are present, with the introns positioned as splice junctions between the major …

Factor VII is a vitamin K-dependent coagulation protein essential for proper hemostasis. The
human Factor VII gene spans 13 kilobase pairs and is located on chromosome 13 just 2.8 …

The factor VII genes of five unrelated Finnish female patients, F1-F5, with moderate bleeding
tendency, were screened for mutations using single strand conformational polymorphisms …

Although small deletions, splice site abnormalities, missense, and nonsense mutations have
been identified in patients with factor VII deficiency, there have been no reports of mutations …

Factor XI is the zymogen of a plasma protease produced primarily in liver that is required for
normal blood coagulation. We cloned∼ 2600 base pairs of the human factor XI gene …

Factor X is a vitamin K-dependent glycoprotein that plays an essential role in both the
intrinsic and extrinsic pathways of blood coagulation. Studies on a recombinant lambda …