[图书][B] The effects of N-(4-hydroxyphenyl) retinamide on retinol and retinol-binding protein metabolism

SJ Ritter - 1995 - search.proquest.com
Abstract The retinoid N-(4-Hydroxyphenyl) retinamide (HPR) effectively inhibits multiple
epithelial derived cancers. HPR rapidly depresses plasma retinol and retinol-binding protein …

Plasma retinol level reduction by the synthetic retinoid fenretinide: a one year follow-up study of breast cancer patients

F Formelli, R Carsana, A Costa, F Buranelli, T Campa… - Cancer Research, 1989 - AACR
Fenretinide (HPR) is a synthetic retinoid which has been shown to cause a reduction in the
incidence of carcinogen-induced epithelial tumors in experimental animals, and it has been …

N-(4-hydroxyphenyl)retinamide: interactions with retinoid-binding proteins/receptors

BP Sani, YF Shealy, DL Hill - Carcinogenesis, 1995 - academic.oup.com
The cellular transport, metabolism and biological activity of retinoids are mediated by their
specific binding proteins and nuclear receptors. For an understanding of the mode of action …

[PDF][PDF] Plasma Retinol Level Reduction by the Synthetic Retinoid Fenretinide: A One Year Follow-up Study of Breast Cancer Patients1

A Magni, M Pizzichetta - academia.edu
Fenretinide (HPR) is a synthetic retinoid which has been shown to cause a reduction in the
incidence of carcinogen-induced epithelial tumors in experimental animals, and it has been …

N-(4-hydroxyphenyl) retinamide (fenretinide) induces retinol-binding protein secretion from liver and accumulation in the kidneys in rats

EM Schaffer, SJ Ritter, JE Smith - The Journal of nutrition, 1993 - Elsevier
ABSTRACT The chemopreventive retinoid N-(4-hydroxyphenyl) retinamide (HPR)
depresses serum retinol and retinol-binding protein (RBP) concentrations. To study long …

Retinol-binding protein secretion from the liver of N-(4-hydroxyphenyl) retinamide-treated rats

SJ Ritter, JE Smith - Biochimica et Biophysica Acta (BBA)-General Subjects, 1996 - Elsevier
N-(4-Hydroxyphenyl) retinamide (HPR; Fenretinide), a synthetic retinoid possessing
antitumor activity, depresses plasma retinol and retinol-binding protein (RBP) …

Effects of chronic administration of N-(4-hydroxyphenyl) retinamide (4-HPR) in rats on vitamin A metabolism in the eye

KC Lewis, LA Zech, JM Phang - European Journal of Cancer, 1996 - Elsevier
The retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) effectively inhibits cancer in a variety
of tissues. In contrast to many other retinoids, the toxicity problems associated with …

Pharmacokinetics of N‐4‐hydroxyphenyl‐retinamide and the effect of its oral administration on plasma retinol concentrations in cancer patients

YM Peng, WS Dalton, DS Alberts, MJ Xu… - … journal of cancer, 1989 - Wiley Online Library
Concurrent with a phase‐II trial of 4HPR in patients with various cancers, we studied the
plasma pharmacokinetics of both 4HPR and its major metabolite 4MPR as well as the effect …

Effects of N-(4-Hydroxyphenyl)retinamide Supplementation on Vitamin A Metabolism

KC Lewis, LA Zech, JM Phang - Cancer research, 1994 - AACR
The efficacy of the retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) has been demonstrated
in the inhibition of cancers in a variety of tissues. Moreover, toxicity effects following …

N-(4-hydroxyphenyl) retinamide (Fenretinide) in combination with retinoic acid enhances differentiation and retinoylation of proteins.

N Takahashi, EA Sausville, TR Breitman - … research: an official journal of the …, 1995 - AACR
Abstract The synthetic retinoid, N-(4-hydroxyphenyl) retinamide (4-HPR; Fenretinide), is a
cancer chemopreventive and antiproliferative agent whose mechanism of action is …