Background & Aims: Hepatic lipocyte proliferation and activation are pivotal in liver fibrosis.
Disruption of normal lipocyte-matrix interactions may contribute to this process. The …

We have examined the expression of the extracellular matrix-degrading metalloprotease
transin/stromelysin during the early phases of rat liver regeneration following toxic injury by …

The expression of genes encoding the core proteins of the novel small chondroitin/dermatan
sulfate proteoglycans decorin and biglycan was studied in the livers of normal rats and in …

Kupffer cells may be involved in liver fibrogenesis through production of TGF-β1. Their role
in fibrinolysis is less clear. Octreotide, a synthetic analogue of somatostatin, is often used in …

Expression of the proteoglycans biglycan and decorin and of transforming growth factor-α1
at various stages of liver fibrosis induced experimentally in rats by oral administration of …

Background/Aims: It is suggested that during fibrogenesis as well as during carcinogenesis
of the liver, the hepatic microvascular phenotype is transformed fromsinusoids-which lack a …

Background/Aims: Activated hepatic stellate cells (HSC) are regarded as the principal cells
synthesizing extracellular matrix components in fibrotic liver. Elastin content is increased in …

Transin is a neutral metalloproteinase initially isolated from malignantly transformed rat
fibroblasts and subsequently shown to be homologous to human stromelysin. We performed …

During culture on uncoated plastic wells rat liver perisinusoidal lipocytes change their
differentiated phenotype (transdifferentiate) within 1–2 weeks and obtain a myofibroblast …

In this study we investigated in rat liver the expression of genes coding for the core proteins
of fibromodulin, lumican and aggrecan. By means of Northern analysis and in situ …