In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression.

MG Frattini, HB Lim, LA Laimins - Proceedings of the …, 1996 - National Acad Sciences
Human papillomavirus (HPV) types 16, 18, 31, and 51 are the etiologic agents of many
anogenital cancers including those of the cervix. These" high risk" HPVs specifically target …

Induction of human papillomavirus type 18 late gene expression and genomic amplification in organotypic cultures from transfected DNA templates

MG Frattini, HB Lim, J Doorbar, LA Laimins - Journal of virology, 1997 - Am Soc Microbiol
The genetic analysis of human papillomavirus (HPV) functions during the vegetative viral life
cycle is dependent upon the ability to generate human keratinocyte cell lines which maintain …

Induction of the human papillomavirus type 31 late promoter requires differentiation but not DNA amplification

KM Spink, LA Laimins - Journal of virology, 2005 - Am Soc Microbiol
The human papillomavirus (HPV) life cycle is linked to the differentiation state of the host
cell. In virus-infected undifferentiated basal epithelial cells, HPV genomes are maintained as …

Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation

MA Bedell, JB Hudson, TR Golub, ME Turyk… - Journal of …, 1991 - Am Soc Microbiol
Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes
as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is …

Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes

M Hummel, JB Hudson, LA Laimins - Journal of virology, 1992 - Am Soc Microbiol
The expression of viral genes during the productive life cycle of human papillomaviruses
(HPV) is tightly coupled to the differentiation program of epithelial cells. We have examined …

Human papillomavirus type 31b infection of human keratinocytes and the onset of early transcription

MA Ozbun - Journal of virology, 2002 - Am Soc Microbiol
Human papillomaviruses (HPVs) cause a number of human tumors and malignancies,
including cervical cancers. Epithelial differentiation is required for the complete HPV life …

Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b

MA Ozbun, C Meyers - Journal of virology, 1997 - Am Soc Microbiol
Human papillomaviruses (HPVs) are etiologic agents of anogenital cancers. The lack of an
efficient in vitro system with which to study the differentiation-dependent viral life cycle has …

Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA

C Meyers, TJ Mayer, MA Ozbun - Journal of virology, 1997 - Am Soc Microbiol
The lack of a permissive system for the propagation of viral stocks containing abundant
human papillomavirus (HPV) particles has hindered the study of infectivity and the early …

Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells

Y Inagaki, Y Tsunokawa, N Takebe, H Nawa… - Journal of …, 1988 - Am Soc Microbiol
HeLa cells expressed 3.4-and 1.6-kilobase (kb) transcripts of the integrated human
papillomavirus (HPV) type 18 genome. Two types of cDNA clones representing each size of …

Role of the E1E4 Protein in the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 31

R Wilson, F Fehrmann, LA Laimins - Journal of virology, 2005 - Am Soc Microbiol
The most highly expressed protein in the productive life cycle of human papillomaviruses
(HPVs) is E1∧ E4, but its function is not well understood. To investigate the role of E1∧ E4 …