[HTML][HTML] Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions inde novo methylation
Promoter region CpG island methylation is associated with tumor suppressor gene silencing
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …
CpG island methylator phenotype in colorectal cancer
M Toyota, N Ahuja, M Ohe-Toyota… - Proceedings of the …, 1999 - National Acad Sciences
Aberrant methylation of promoter region CpG islands is associated with transcriptional
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …
inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG …
Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived
A higher prevalence of epigenetic inactivation of tumor suppressor genes has been reported
in cancer cell line populations compared to primary cancer populations. Cancer-related …
in cancer cell line populations compared to primary cancer populations. Cancer-related …
CpG island methylator phenotypes in aging and cancer
M Toyota, JPJ Issa - Seminars in cancer biology, 1999 - Elsevier
CpG islands are short stretches of CpG rich regions that are frequently associated with the
promoter region of genes. Aberrant methylation of CpG islands is one mechanism of …
promoter region of genes. Aberrant methylation of CpG islands is one mechanism of …
Evidence for an instructive mechanism of de novo methylation in cancer cells
I Keshet, Y Schlesinger, S Farkash, E Rand, M Hecht… - Nature …, 2006 - nature.com
DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …
development but can also mediate epigenetic silencing of CpG island genes in cancer and …
Epigenetic gene silencing in cancer initiation and progression
KP Nephew, THM Huang - Cancer letters, 2003 - Elsevier
Hypermethylation of CpG islands, an epigenetic event that is not accompanied by changes
in DNA sequence, represents an alternative mechanism to deletions or mutations to …
in DNA sequence, represents an alternative mechanism to deletions or mutations to …
Aberrant CpG-island methylation has non-random and tumour-type–specific patterns
JF Costello, MC Frühwald, DJ Smiraglia, LJ Rush… - Nature …, 2000 - nature.com
CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …
The role of DNA hypermethylation in human neoplasia
M Toyota, JPJ Issa - ELECTROPHORESIS: An International …, 2000 - Wiley Online Library
Cancer development and progression is dictated by a series of alterations in genes such as
oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an …
oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an …
High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
F Antequera, J Boyes, A Bird - Cell, 1990 - cell.com
CpG islands are normally methylation free in cells of the animal, even when the associated
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
gene is transcriptionally silent. In mouse NIH 3T3 and L cells, however, over half of the …
DNA methylation and chromatin structure: the puzzling CpG islands
P Caiafa, M Zampieri - Journal of cellular biochemistry, 2005 - Wiley Online Library
DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …