Microsatellite instability (MI+) is associated with defects in mismatch repair, resulting in a
'mutator'phenotype and the development and progression of cancer. MI+ has been …

We analysed 50 gastric carcinomas (GCs) to verify whether mutations at coding repeats
were associated with microsatellite instability (MSI). The tumors included: ten cases with no …

Frequent deletions of the distal region on the long arm of chromosome 6 have been reported
in multiple human tumors including B-cell non-Hodgkin lymphoma (B-NHL), suggesting the …

Publisher Summary The chapter presents three categories of mechanisms of immune
escape:(1) loss or absence of targetable surface epitopes,(2) synthesis by the tumor cell of …

DNA mismatch binding by an extensively purified hMutSα mismatch recognition complex
was investigated using a bandshift assay. The complex bound to G· T mispairs and to …

To establish a cause–effect relationship between the human mismatch repair pathway
deficiency and the observed phenotypes, a hMSH2 deficient HeLa cell line (HeLa-MSH2−) …

Genetic instability Is closely correlated to the pathogenesis of hereditary non‐palyposis
colon cancer (HNPCC), which is clinicaily characterized by a family history and early onset …

Fifty‐two sporadic primary non‐small‐cell lung carcinomas (NSCLC) were examined for
microsatellite instability. Six different microsatellite markers localized on chromosomes 2, 5 …

It has been recognized that gastric cancer often shows histological heterogeneity in a single
tumor. Although microsatellite instability (MSI) has been reported in gastric cancer, the …

In order to examine their roles in carcinogenesis or in progression of colorectal carcinoma,
we investigated telomerase activity and microsatellite instability in 67 non-familial colorectal …