Cancer is a genetic disorder in which gene alterations are selected to provide growth
advantage by oncogene activation and/or tumor suppressor gene inactivation. Even marked …

MSH6 has been implicated in repair of single base mispairs and single‐base
deletion/insertion mutations. Established MSH6‐null mice present a frequent occurrence of …

No area of science has advanced our understanding of human disorders as rapidly as
molecular genetics and biology. In recent years, the application of many molecular and …

Studies of human mismatch repair were stimulated by the finding that mutations in genes
encoding mismatch repair factors underlie the inherited predisposition to colorectal and …

Nucleotide excision repair (NER) is the main process used by cells to remove bulky lesions
from DNA (reviewed in Friedberg et al. 1995). The molecular details of its mechanism have …

Genetic instability due to a DNA mismatch repair deficiency leads to the replication error
(RER) phenotype in cancer cells. Certain loci are more susceptible to replication errors than …

Previous cytogenetic studies of multiple human tumor types, including B-cell non-Hodgkin's
lymphoma (B-NHL), have reported frequent deletions on the long arm of chromosome 6 …

HCC is a multistep genetic disease in which many genomic changes occur as a result of
uncontrolled proliferation of hepatocytes. Molecular events leading to HCC is still unclear …

はじめに癌 は, 突然変異による癌遺伝子の活性化や癌抑制遺伝子の欠失によって引 き起 こされ
る無制限な細胞増殖である. その発生メカニズムにっいては, 細胞 に何 らかの発癌に関わる遺伝子 …

The TATA box binding protein (TBP) plays an essential role in eukaryotic gene expression.
A characteristic feature of the human TBP is a stretch of glutamine residues in the amino …