Yeast ARMs (DNA at-risk motifs) can reveal sources of genome instability
DA Gordenin, MA Resnick - Mutation Research/Fundamental and …, 1998 - Elsevier
The genomes of all organisms contain an abundance of DNA repeats which are at-risk for
causing genetic change. We have used the yeast Saccharomyces cerevisiae to investigate …
causing genetic change. We have used the yeast Saccharomyces cerevisiae to investigate …
Replication Slippage between Distant Short Repeats in Saccharomyces cerevisiae Depends on the Direction of Replication and the RAD50 and RAD52 Genes
HT Tran, NP Degtyareva, NN Koloteva… - … and Cellular Biology, 1995 - Taylor & Francis
Small direct repeats, which are frequent in all genomes, are a potential source of genome
instability. To study the occurrence and genetic control of repeat-associated deletions, we …
instability. To study the occurrence and genetic control of repeat-associated deletions, we …
Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae
DNA sequences capable of adopting non-canonical secondary structures have been
associated with gross-chromosomal rearrangements in humans and model organisms …
associated with gross-chromosomal rearrangements in humans and model organisms …
Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae
ET Young, JS Sloan, K Van Riper - Genetics, 2000 - academic.oup.com
The genome of Saccharomyces cerevisiae contains numerous unstable microsatellite
sequences. Mononucleotide and dinucleotide repeats are rarely found in ORFs, and when …
sequences. Mononucleotide and dinucleotide repeats are rarely found in ORFs, and when …
[HTML][HTML] Long inverted repeats in eukaryotic genomes: recombinogenic motifs determine genomic plasticity
Inverted repeats are unstable motifs in a genome, having a causal relation to fragment
rearrangements and recombination events. We have investigated long inverted repeats …
rearrangements and recombination events. We have investigated long inverted repeats …
Cis-Elements Governing Trinucleotide Repeat Instability in Saccharomyces cerevisiae
ML Rolfsmeier, MJ Dixon, L Pessoa-Brandao… - Genetics, 2001 - academic.oup.com
Trinucleotide repeat (TNR) instability in humans is governed by unique cis-elements. One
element is a threshold, or minimal repeat length, conferring frequent mutations. Since …
element is a threshold, or minimal repeat length, conferring frequent mutations. Since …
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
AN Khristich, SM Mirkin - Journal of Biological Chemistry, 2020 - ASBMB
Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …
majority of which are severe, degenerative, and not currently treatable or preventable. In this …
The effect of DNA replication mutations on CAG tract stability in yeast
JK Schweitzer, DM Livingston - Genetics, 1999 - academic.oup.com
CAG repeat tracts are unstable in yeast, leading to frequent contractions and infrequent
expansions in repeat tract length. To compare CAG repeats to other simple repeats and …
expansions in repeat tract length. To compare CAG repeats to other simple repeats and …
Differential distribution of simple sequence repeats in eukaryotic genome sequences
MV Katti, PK Ranjekar, VS Gupta - Molecular biology and …, 2001 - academic.oup.com
Complete chromosome/genome sequences available from humans, Drosophila
melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, and Saccharomyces …
melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, and Saccharomyces …
Quantitative analysis of the rates for repeat-mediated genome instability in a yeast experimental system
EA Radchenko, RJ McGinty, AY Aksenova… - … Instability: Methods and …, 2018 - Springer
Instability of repetitive DNA sequences causes numerous hereditary disorders in humans,
the majority of which are associated with trinucleotide repeat expansions. Here, we describe …
the majority of which are associated with trinucleotide repeat expansions. Here, we describe …