The genomes of all organisms contain an abundance of DNA repeats which are at-risk for
causing genetic change. We have used the yeast Saccharomyces cerevisiae to investigate …

Small direct repeats, which are frequent in all genomes, are a potential source of genome
instability. To study the occurrence and genetic control of repeat-associated deletions, we …

DNA sequences capable of adopting non-canonical secondary structures have been
associated with gross-chromosomal rearrangements in humans and model organisms …

The genome of Saccharomyces cerevisiae contains numerous unstable microsatellite
sequences. Mononucleotide and dinucleotide repeats are rarely found in ORFs, and when …

Inverted repeats are unstable motifs in a genome, having a causal relation to fragment
rearrangements and recombination events. We have investigated long inverted repeats …

Trinucleotide repeat (TNR) instability in humans is governed by unique cis-elements. One
element is a threshold, or minimal repeat length, conferring frequent mutations. Since …

Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

CAG repeat tracts are unstable in yeast, leading to frequent contractions and infrequent
expansions in repeat tract length. To compare CAG repeats to other simple repeats and …

Complete chromosome/genome sequences available from humans, Drosophila
melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, and Saccharomyces …

Instability of repetitive DNA sequences causes numerous hereditary disorders in humans,
the majority of which are associated with trinucleotide repeat expansions. Here, we describe …