[HTML][HTML] Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C: Evidence for Vav-hnRNP interactions in an RNA-dependent manner
F Romero, A Germani, E Puvion, J Camonis… - Journal of Biological …, 1998 - ASBMB
The vav proto-oncogene is exclusively expressed in hematopoietic cells and encodes a 95-
kDa protein that contains multiple structural domains. Vav is involved in the expansion of T …
kDa protein that contains multiple structural domains. Vav is involved in the expansion of T …
Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins
XR Bustelo, KL Suen, WM Michael… - … and cellular biology, 1995 - Taylor & Francis
We have used the yeast two-hybrid system to isolate proteins that interact with the carboxy-
terminal SH3-SH2-SH3 region of Vav. One of the clones encoded heterogeneous nuclear …
terminal SH3-SH2-SH3 region of Vav. One of the clones encoded heterogeneous nuclear …
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
LE Marengere, C Mirtsos, I Kozieradzki… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
The molecular adapter c-Cbl is rapidly tyrosine phosphorylated following stimulation through
the TCR and associates with Src homology domain-2 (SH2)/SH3 domain-containing …
the TCR and associates with Src homology domain-2 (SH2)/SH3 domain-containing …
[HTML][HTML] A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation
MR Kuhne, G Ku, A Weiss - Journal of Biological Chemistry, 2000 - ASBMB
T cell antigen receptor (TCR) stimulation induces the tyrosine phosphorylation of several
intracellular proteins including the protooncogene Vav1. Vav1 expression is necessary for …
intracellular proteins including the protooncogene Vav1. Vav1 expression is necessary for …
Vav: A potential link between tyrosine kinases and Ras‐like GTPases in hematopoietic cell signaling
P Hu, B Margolis, J Schlessinger - Bioessays, 1993 - Wiley Online Library
The vav proto‐oncogene encodes a 95 kDa protein which is expressed exclusively in
hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the …
hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the …
Genomic organization and regulation of the vav proto-oncogene
DJ Denkinger, CR Borges, CL Butler… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Vav and vav2 are members of the dbl family of guanine nucleotide exchange factors (GEF)
for the rho/rac family of GTP binding proteins. Vav is expressed primarily in hematopoietic …
for the rho/rac family of GTP binding proteins. Vav is expressed primarily in hematopoietic …
Vav: function and regulation in hematopoietic cell signaling
N Bonnefoy-Bérard, A Munshi, I Yron, S Wu… - Stem Cells, 1996 - academic.oup.com
Vav, a 95 kDa proto-oncogene product expressed specifically in hematopoietic cells, was
originally isolated as a transforming human oncogene. Vav contains an array of functional …
originally isolated as a transforming human oncogene. Vav contains an array of functional …
Mechanism of activation of the vav protooncogene
J Coppola, S Bryant, T Koda, D Conway, M Barbacid - Cell Growth Differ, 1991 - AACR
Abstract vav is a human locus that appears to be specifically expressed in cells of
hematopoietic origin regardless of their differentiation lineage. This gene was first identified …
hematopoietic origin regardless of their differentiation lineage. This gene was first identified …
Views on Vav
TL Collins, M Deckert, A Altman - Immunology today, 1997 - cell.com
Vav is a 95 kDa prolooncogene product whose expression is largely limited to cells of
hematopoietic origin. Although reports on the role of Vav in Ras activation have generated …
hematopoietic origin. Although reports on the role of Vav in Ras activation have generated …
Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav
M López-Lago, H Lee, C Cruz, N Movilla… - … and cellular biology, 2000 - Am Soc Microbiol
Vav works as a GDP/GTP exchange factor for Rac GTPases, thereby facilitating the
transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state …
transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state …