The vav proto-oncogene is exclusively expressed in hematopoietic cells and encodes a 95-
kDa protein that contains multiple structural domains. Vav is involved in the expansion of T …

We have used the yeast two-hybrid system to isolate proteins that interact with the carboxy-
terminal SH3-SH2-SH3 region of Vav. One of the clones encoded heterogeneous nuclear …

The molecular adapter c-Cbl is rapidly tyrosine phosphorylated following stimulation through
the TCR and associates with Src homology domain-2 (SH2)/SH3 domain-containing …

T cell antigen receptor (TCR) stimulation induces the tyrosine phosphorylation of several
intracellular proteins including the protooncogene Vav1. Vav1 expression is necessary for …

The vav proto‐oncogene encodes a 95 kDa protein which is expressed exclusively in
hematopoietic cells. Analysis of the deduced amino acid sequence has revealed the …

Vav and vav2 are members of the dbl family of guanine nucleotide exchange factors (GEF)
for the rho/rac family of GTP binding proteins. Vav is expressed primarily in hematopoietic …

Vav, a 95 kDa proto-oncogene product expressed specifically in hematopoietic cells, was
originally isolated as a transforming human oncogene. Vav contains an array of functional …

Abstract vav is a human locus that appears to be specifically expressed in cells of
hematopoietic origin regardless of their differentiation lineage. This gene was first identified …

Vav is a 95 kDa prolooncogene product whose expression is largely limited to cells of
hematopoietic origin. Although reports on the role of Vav in Ras activation have generated …

Vav works as a GDP/GTP exchange factor for Rac GTPases, thereby facilitating the
transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state …