Disruption of the DNA mismatch repair system, characterized by microsatellite instability
(MI), plays an important role in the course of human carcinogenesis by increasing the rate of …

Half of colorectal tumors with microsatellite instability contain frameshift mutations in the (G)
8 tract of bax, a major apoptosis effector, but their functional significance remains unclear …

We have reported previously that codon 169 of the proapoptotic gene BAX is a mutational
hot spot in gastrointestinal cancer. Two different mutations were found in this codon …

AIMS: Spontaneous apoptosis and expression of the apoptotic regulatory proteins Bax, Bcl-
x, and Bcl-2 were investigated in 50 colorectal carcinomas. The p53 genotypes/phenotypes …

Widespread microsatellite instability (MSI) due to the defective DNA mismatch repair
underlies the pathogenesis of the majority of hereditary non-polyposis colorectal cancer and …

Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic
instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ …

BAX gene mutations occur in approximately 50% of RER+ colorectal cancers. To determine
the role of these mutations in tumour progression we analysed multiple different tumour sites …

A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer
of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene …

Microsatellite instability in sporadic colon cancer is associated with an improved prognosis.
Recent studies, however, have suggested that microsatellite unstable cancers with …

Though most colorectal cancers show allelic losses, a subset of colorectal cancers
(microsatellite instability or MSI-positive cancers) develop numerous small insertion and …