The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.
H Ouyang, T Furukawa, T Abe, Y Kato, A Horii - Clinical cancer research: an …, 1998 - AACR
Disruption of the DNA mismatch repair system, characterized by microsatellite instability
(MI), plays an important role in the course of human carcinogenesis by increasing the rate of …
(MI), plays an important role in the course of human carcinogenesis by increasing the rate of …
Role of bax Mutations in Apoptosis in Colorectal Cancers With Microsatellite Instability
C Miquel, F Borrini, S Grandjouan… - American journal of …, 2005 - academic.oup.com
Half of colorectal tumors with microsatellite instability contain frameshift mutations in the (G)
8 tract of bax, a major apoptosis effector, but their functional significance remains unclear …
8 tract of bax, a major apoptosis effector, but their functional significance remains unclear …
Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers
We have reported previously that codon 169 of the proapoptotic gene BAX is a mutational
hot spot in gastrointestinal cancer. Two different mutations were found in this codon …
hot spot in gastrointestinal cancer. Two different mutations were found in this codon …
Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype.
PM De Angelis, T Stokke, L Thorstensen… - Molecular …, 1998 - ncbi.nlm.nih.gov
AIMS: Spontaneous apoptosis and expression of the apoptotic regulatory proteins Bax, Bcl-
x, and Bcl-2 were investigated in 50 colorectal carcinomas. The p53 genotypes/phenotypes …
x, and Bcl-2 were investigated in 50 colorectal carcinomas. The p53 genotypes/phenotypes …
Frequent Bax frameshift mutations in gastric cancer with high but not low microsatellite instability.
H Yamamoto, F Itoh, H Fukushima… - … of Experimental & …, 1999 - europepmc.org
Widespread microsatellite instability (MSI) due to the defective DNA mismatch repair
underlies the pathogenesis of the majority of hereditary non-polyposis colorectal cancer and …
underlies the pathogenesis of the majority of hereditary non-polyposis colorectal cancer and …
Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype
N Rampino, H Yamamoto, Y Ionov, Y Li, H Sawai… - Science, 1997 - science.org
Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic
instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ …
instability at simple repeat sequences. More than 50 percent (21 out of 41) of human MMP+ …
Role of BAX mutations in mismatch repair-deficient colorectal carcinogenesis
WM Abdel-Rahman, IB Georgiades, LJ Curtis… - Oncogene, 1999 - nature.com
BAX gene mutations occur in approximately 50% of RER+ colorectal cancers. To determine
the role of these mutations in tumour progression we analysed multiple different tumour sites …
the role of these mutations in tumour progression we analysed multiple different tumour sites …
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution
Y Ionov, H Yamamoto, S Krajewski… - Proceedings of the …, 2000 - National Acad Sciences
A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer
of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene …
of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene …
Prognostic implications of BAX and TGFBRII mutations in colon cancers with microsatellite instability
WS Samowitz, K Curtin, S Neuhausen… - Genes …, 2002 - Wiley Online Library
Microsatellite instability in sporadic colon cancer is associated with an improved prognosis.
Recent studies, however, have suggested that microsatellite unstable cancers with …
Recent studies, however, have suggested that microsatellite unstable cancers with …
Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers
LA Simms, G Radford-Smith, KG Biden, R Buttenshaw… - Oncogene, 1998 - nature.com
Though most colorectal cancers show allelic losses, a subset of colorectal cancers
(microsatellite instability or MSI-positive cancers) develop numerous small insertion and …
(microsatellite instability or MSI-positive cancers) develop numerous small insertion and …