Microsatellite instability and mutation of DNA mismatch repair genes in gliomas

SY Leung, TL Chan, LP Chung, ASY Chan… - The American journal of …, 1998 - Elsevier
Microsatellite instability (MSI) has been identified in various human cancers, particularly
those associated with the hereditary nonpolyposis colorectal cancer syndrome. Although …

Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas

Q Wei, ML Bondy, L Mao, Y Guan, L Cheng… - Cancer research, 1997 - AACR
Microsatellite instability (MIN) is frequently observed in hereditary nonpolyposis colon
cancer and in other sporadic cancers including gliomas. Abnormalities in at least one of five …

Microsatellite instability in pediatric and adult high‐grade gliomas

A Eckert, M Kloor, A Giersch, R Ahmadi… - Brain …, 2007 - Wiley Online Library
About 15% of sporadic gastrointestinal and endometrial tumors show the microsatellite
instability (MSI) phenotype because of loss of DNA mismatch repair (MMR) function. The …

Microsatellite instability occurs in distinct subtypes of pediatric but not adult central nervous system tumors

M Alonso, R Hamelin, M Kim, K Porwancher, T Sung… - Cancer research, 2001 - AACR
Length alterations in microsatellite repeats, termed microsatellite instability (MSI), are found
in 10–15% of sporadic colon, endometrial, and gastric cancers harboring defects in DNA …

Microsatellite Instability in Colorectal Cancer: Different Mutator Phenotypes and the Principal Involvement of hMLH1

SN Thibodeau, AJ French, JM Cunningham, D Tester… - Cancer research, 1998 - AACR
Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colorectal cancer and in a large number of …

Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene …

SY Leung, ST Yuen, TL Chan, ASY Chan, JWC Ho… - Oncogene, 2000 - nature.com
We have previously reported high-frequency microsatellite instability (MSI-H) and germ-line
mismatch repair gene mutation in patients with unusually young onset of high-grade glioma …

Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.

VJ Bubb, LJ Curtis, C Cunningham, MG Dunlop… - Oncogene, 1996 - europepmc.org
Microsatellite instability (MSI) occurs in most tumours from patients with hereditary non-
polyposis colorectal cancer (HNPCC) and in around 17% of sporadic colorectal cancers …

Causes of microsatellite instability in colorectal tumors: implications for hereditary non-polyposis colorectal cancer screening

U Potočnik, D Glavač, R Golouh… - Cancer genetics and …, 2001 - Elsevier
Microsatellite instability (MSI) analysis was performed using a “reference panel” of
microsatellite markers in 345 unselected primary colorectal cancers (CRC). Thirty-five (10%) …

Microsatellite instability in gastrointestinal tract cancers: a brief update

S Oda, Y Zhao, Y Maehara - Surgery today, 2005 - Springer
Microsatellite instability (MSI) was initially reported in colorectal cancer and, particularly, in
hereditary nonpolyposis colorectal cancer (HNPCC). Since mutations in the genes …

Microsatellite instability in malignant melanoma

VR Talwalkar, M Scheiner, LK Hedges… - Cancer genetics and …, 1998 - Elsevier
Defective mismatch repair has been detected in human colorectal and endometrial
carcinomas which exhibit microsatellite instability (MIN). The purpose of this study was to …