The role, if any, that mitochondrial (mt) DNA alterations play in the carcinogenic process
remains unclear. To determine whether mtDNA instability occurs in cancers, nine …

We have shown that microsatellite instability (MSI) occurs in mitochondrial DNA (mtDNA) of
colorectal carcinomas. To determine whether such mitochondrial microsatellite instability …

Mitochondrial DNA (mtDNA) large deletions and mtDNA mutations have been demonstrated
in various types of human cancer. The relationship between the occurrence of such …

Malfunction of mismatch repair (MMR) genes produces nuclear genome instability (NGI) and
plays an important role in the origin of some hereditary and sporadic human cancers. The …

Mitochondrial DNA (mtDNA) instability has been observed in different types of cancer,
including colorectal, breast, and gastric cancer. The relationship between the occurrence of …

An increase in the rate of glycolysis is one of the metabolic alterations in most cancer cells.
However, the role of alterations in mitochondrial function and mitochondrial DNA (mtDNA) in …

Background & Aims: Microsatellite instability (MSI) in mitochondrial DNA (mtDNA) is
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI …

Recent studies of various cancers, such as those of the breast, head and neck, bladder and
lung, reported that 46–64% of somatic mutations in the D-loop region of mitochondrial DNA …

Somatic mutations at a mitochondrial noncoding polycytidine (C) n repeat (polyC) have
been associated with tumor progression. We analyzed whether these alterations are due to …

The region of the human mitochondrial D-loop has been sequenced from DNA of colonic
tumors and paired normal colonic tissue to determine if mutations in the promotors for the …