Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome
W Habano, S Nakamura, T Sugai - Oncogene, 1998 - nature.com
The role, if any, that mitochondrial (mt) DNA alterations play in the carcinogenic process
remains unclear. To determine whether mtDNA instability occurs in cancers, nine …
remains unclear. To determine whether mtDNA instability occurs in cancers, nine …
Mitochondrial gene mutation, but not large‐scale deletion, is a feature of colorectal carcinomas with mitochondrial microsatellite instability
W Habano, T Sugai, T Yoshida… - International journal of …, 1999 - Wiley Online Library
We have shown that microsatellite instability (MSI) occurs in mitochondrial DNA (mtDNA) of
colorectal carcinomas. To determine whether such mitochondrial microsatellite instability …
colorectal carcinomas. To determine whether such mitochondrial microsatellite instability …
Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma
Mitochondrial DNA (mtDNA) large deletions and mtDNA mutations have been demonstrated
in various types of human cancer. The relationship between the occurrence of such …
in various types of human cancer. The relationship between the occurrence of such …
Mitochondrial genome instability in human cancers
Malfunction of mismatch repair (MMR) genes produces nuclear genome instability (NGI) and
plays an important role in the origin of some hereditary and sporadic human cancers. The …
plays an important role in the origin of some hereditary and sporadic human cancers. The …
mtDNA mutations in tumors of the central nervous system reflect the neutral evolution of mtDNA in populations
A Vega, A Salas, E Gamborino, MJ Sobrido… - Oncogene, 2004 - nature.com
Mitochondrial DNA (mtDNA) instability has been observed in different types of cancer,
including colorectal, breast, and gastric cancer. The relationship between the occurrence of …
including colorectal, breast, and gastric cancer. The relationship between the occurrence of …
Mitochondrial genome instability and mtDNA depletion in human cancers
HC LEE, PENHUI YIN, JINC LIN, CC WU… - Annals of the New …, 2005 - Wiley Online Library
An increase in the rate of glycolysis is one of the metabolic alterations in most cancer cells.
However, the role of alterations in mitochondrial function and mitochondrial DNA (mtDNA) in …
However, the role of alterations in mitochondrial function and mitochondrial DNA (mtDNA) in …
Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma
W Habano, T Sugai, SI Nakamura, N Uesugi… - Gastroenterology, 2000 - Elsevier
Background & Aims: Microsatellite instability (MSI) in mitochondrial DNA (mtDNA) is
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI …
observed in some colorectal carcinomas. We attempted to determine if mitochondrial MSI …
Frequent somatic mutations of mitochondrial DNA in esophageal squamous cell carcinoma
H Kumimoto, Y Yamane, Y Nishimoto… - … journal of cancer, 2004 - Wiley Online Library
Recent studies of various cancers, such as those of the breast, head and neck, bladder and
lung, reported that 46–64% of somatic mutations in the D-loop region of mitochondrial DNA …
lung, reported that 46–64% of somatic mutations in the D-loop region of mitochondrial DNA …
Mutational dynamics in human tumors confirm the neutral intrinsic instability of the mitochondrial D‐loop poly‐cytidine repeat
S Schwartz Jr, H Alazzouzi… - Genes, Chromosomes …, 2006 - Wiley Online Library
Somatic mutations at a mitochondrial noncoding polycytidine (C) n repeat (polyC) have
been associated with tumor progression. We analyzed whether these alterations are due to …
been associated with tumor progression. We analyzed whether these alterations are due to …
Polymorphisms, but lack of mutations or instability, in the promotor region of the mitochondrial genome in human colonic tumors
BG Heerdt, J Chen, LR Stewart, LH Augenlicht - Cancer research, 1994 - AACR
The region of the human mitochondrial D-loop has been sequenced from DNA of colonic
tumors and paired normal colonic tissue to determine if mutations in the promotors for the …
tumors and paired normal colonic tissue to determine if mutations in the promotors for the …
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