To determine whether loss of mismatch repair (MMR) confers sensitivity to N-(2-chloroethyl)-
N′-cyclohexyl-N-nitrosourea (CCNU), the sensitivity of MMR-defective (MMR-) variants was …

Together with tolerance to killing induced by methylating agents, loss of mismatch repair
(MMR) has previously been found to be associated with hypersensitivity to the DNA cross …

The contributions of defective mismatch repair (MMR) and the p53-response to cell killing by
N-(2-chloroethyl)-N′-cyclohexyl-N-nitrosourea (CCNU) were evaluated. MMR defects were …

Resistance to the cytotoxic effects of SN1 alkylating agents such as N-methyl-N′-nitro-N-
nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) is well established in …

Cells with the mutator phenotype are tolerant to methylating damage from N-
methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanine, exhibit replication repair …

The phenomenon of alkylation tolerance has been observed in cells that are deficient in
some component of the DNA mismatch repair (MMR) system. An alkylation-induced cell …

Fifteen variants with≥ 30-fold resistance toN-methyl-N-nitrosourea were isolated from the
Burkitt's lymphoma Raji cell line. Eight had received a single treatment with a highly …

Mismatch repair (MMR) deficiency was reported to increase resistance of mammalian cells
to killing by several genotoxic substances. However, although MMR-deficient cells are∼ …

Abstract The Mex−(Mer−) phenotype of human cells is characterised by a sensitivity to
agents such as N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea …

O 6-methylguanine is responsible for homologous recombination induced by N-methyl-N′-
nitro-N-nitrosoguanidine (MNNG)[H. Zhang et al.(1996) Carcinogenesis, 17, 2229]. To test …