Adaptations at the cellular and molecular levels in response to stress and antidepressant
treatment could represent a form of neural plasticity that contributes to the pathophysiology …

Objective: We review the literature on the cellular changes that underlie the structural
impairments observed in brains of animals exposed to stress and in subjects with …

Studies at the basic and clinical levels demonstrate that neuronal atrophy and cell death
occur in response to stress and in the brains of depressed patients. Although the …

The hippocampus is one of several limbic brain structures implicated in the pathophysiology
and treatment of mood disorders. Preclinical and clinical studies demonstrate that stress and …

Neuronal plasticity or remodeling is most often discussed with regard to cellular and
behavioral models of learning and memory. However, neuronal plasticity is a fundamental …

BackgroundNew research in animals is beginning to change radically our understanding of
the biology of stress and the effects of antidepressant agents. AimsTo relate recent findings …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

Recent studies have begun to characterize the actions of stress and antidepressant
treatments beyond the neurotransmitter and receptor level. This work has demonstrated that …

Structural and morphological changes in limbic brain regions are associated with
depression, chronic stress and antidepressant treatment, and increasing evidence supports …

It is widely accepted that changes underlying depression and antidepressant‐like effects
involve not only alterations in the levels of neurotransmitters as monoamines and their …