The rapid (lKr) and slow (IKs) delayed rectifier K+ currents are key regulators of cardiac
repolarization. HERG encodes the Kr channel, and KVLQT1 and hminK encode subunits …

Normal cardiac action potential repolarization is dependent on activation of several K+
currents, including IKr and IKs. IKr activates rapidly at positive potentials, exhibits inward …

Mutations in the delayed rectifier K+ channel subunit KvLQT1 have been identified as
responsible for both Romano–Ward (RW) and Jervell and Lange-Nielsen (JLN) inherited …

Mutations in KvLQT1. Introduction: The long QT syndrome (LQT) is caused by mutations in
genes encoding ion channels that modulate the duration of ventricular action potentials. One …

Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death
from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel …

Delayed rectifier K+ current in cardiac myocytes is the sum of two distinct currents, IKr and
IKs. The molecular basis of these channels has recently been defined. HERG subunits …

The short QT syndrome constitutes a new clinical entity that is associated with a high
incidence of sudden cardiac death, syncope, and/or atrial fibrillation even in young patients …

The long QT syndrome is characterized by prolonged cardiac repolarization and a high risk
of sudden death. Mutations in the KCNQ1 gene, which encodes the cardiac KvLQT1 …

Introduction gene, HERG, whose protein product likely underlies IKr, the rapidly activating
delayed rectifier current Congenital long QT syndrome (LQT) is a potentially treatable …

The inherited long QT syndrome (LQTS), characterized by a prolonged QT interval in the
electrocardiogram and cardiac arrhythmia, is caused by mutations in at least four different …