Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or
neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing …

The induction of synthesis or release of endogenous neurotrophic factors in the brain by low-
molecular-weight drugs could be a feasible alternative for the direct administration of …

Increasing number of studies has during the last decade linked neurotrophic factors with the
pathophysiology of neuropsychiatric disorders and with the mechanisms of action of drugs …

Brain-derived neurotrophic factor (BDNF) is a member of the structurally and functionally
homologous neurotrophin family. It is the most widely distributed trophic factor in the brain …

Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Neurotrophins and other growth factors have been advanced as critical modulators of
depressive behavior. Support for this model is based on analyses of knockout and …

How do antidepressants elicit an antidepressant response? Here, we review accumulating
evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a …

Although neurotrophins have been postulated to have antidepressant properties, their effect
on anxiety is not clear. We find that transgenic overexpression of the neurotrophin BDNF has …

BACKGROUND: The protein p11 (also called S100A10) is downregulated in human and
rodent depressive-like states. Considerable experimental evidence also implicates p11 in …