A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats

LJMJ Vanderschuren, ED Schmidt… - Journal of …, 1999 - Soc Neuroscience
Repeated treatment with psychostimulant drugs causes long-lasting behavioral sensitization
and associated neuroadaptations. Although sensitization induced by a single …

A single exposure to morphine induces long‐lasting behavioural and neurochemical sensitization in rats

LJMJ Vanderschuren, TJ De Vries… - European Journal of …, 2001 - Wiley Online Library
Repeated exposure to drugs of abuse causes persistent behavioural sensitization and
associated adaptations in striatal neurotransmission, which is thought to play an important …

Critical role of the hypothalamic pituitary adrenal axis in amphetamine-induced sensitization of behavior

BJ Cole, M Cador, L Stinus, C Rivier, J Rivier, W Vale… - Life sciences, 1990 - Elsevier
Behavioral sensitization can be observed with repeated administration of amphetamine
where the intensity of motor stimulation increases over time. The process of sensitization has …

Evidence of a complete independence of the neurobiological substrates for the induction and expression of behavioral sensitization to amphetamine

M Cador, Y Bjijou, L Stinus - Neuroscience, 1995 - Elsevier
The repeated administration of amphetamine in rats produces behavioral sensitization
which is characterized either by a progressive enhancement of the locomotor activity …

[PDF][PDF] Behavioral sensitization is accompanied by an enhancement in amphetamine-stimulated dopamine release from striatal tissue in vitro

TE Robinson, JB Becker - 1982 - deepblue.lib.umich.edu
The repeated administration of amphetamine (AMPH) produces a long-lasting facilitation in
the behavioral responsiveness to subsequent AMPH injections. This sensitization has been …

Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior

CR Ferrario, TE Robinson - European neuropsychopharmacology, 2007 - Elsevier
It has been proposed that some neuroadaptations that underlie behavioral sensitization may
play a role in the development and persistence of addiction. However, whether or not …

Circulating adrenal hormones are not necessary for the development of sensitization to the psychomotor activating effects of amphetamine

A Badiani, MI Morano, H Akil, TE Robinson - Brain research, 1995 - Elsevier
We reported previously that when amphetamine is given in NOVEL test cages both its acute
psychomotor activating effects (rotational behavior and locomotor activity) and the degree of …

Exposure to repeated, intermittent d-amphetamine induces sensitization of HPA axis to a subsequent stressor

AM Barr, BACE Hofmann, J Weinberg… - …, 2002 - Elsevier
Previous studies have demonstrated that exposure to psychostimulant drugs can produce a
lasting cross-sensitization to the behavioral effects of stress. The main purpose the present …

Susceptibility to sensitization. II. The influence of gonadal hormones on enduring changes in brain monoamines and behavior produced by the repeated …

DM Camp, TE Robinson - Behavioural brain research, 1988 - Elsevier
Repeated amphetamine use produces an enduring sensitization of brain dopamine (DA)
systems and behavior. Repeated exposure to stress can also produce sensitization, and …

Changes in brain norepinephrine associated with sensitization to d-amphetamine

PH Short, L Shuster - Psychopharmacology, 1976 - Springer
Abstract Pretreatment of B6AF 1/J mice with d-amphetamine HCl 10 mg/kg, twice daily for 5
days, produced a 4-fold increase in the running response to a test dose of 5 mg/kg …