The authors predict that in a few years, many areas of psychology will be awash in specific
genes responsible for the widespread influence of genetics on behavior. As the focus shifts …

Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

Alzheimer's disease is characterised by the degeneration of selected populations of nerve
cells that develop filamentous inclusions prior to degeneration. The neuronal inclusions of …

APP23 transgenic mice overexpress human APP with the Swedish double mutation. The
mice start to develop amyloid plaque pathology at about six months of age, followed …

Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In
Alzheimer's disease, for example, the amyloid β-peptide (Aβ) is the main component of the …

Clinical differential diagnosis of early-onset dementia (EOD) includes familial Alzheimer
disease (FAD) and hereditary prion disease. In both disease entities, postmortem brain …

One of the most significant developments in biology in the past half century was the
emergence, in the late 1950s and early 1960s, of neuroscience as a distinct discipline. We …

▪ Abstract The amyloidoses are diseases in which abnormalities in the secondary structure
of precursor proteins result in decreased solubility under physiologic conditions, with …

Tissue transglutaminase is a multifunctional protein that is likely to play a role in numerous
processes in the nervous system. Tissue transglutaminase posttranslationally modifies …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly population.
Dementia is associated with massive accumulation of fibrillary aggregates in various cortical …