There is evidence for genetic contributions to reading disability, but the phenotypic
heterogeneity associated with the clinical diagnosis may make identification of the …

The etiology of late-onset Alzheimer's disease (AD) and idiopathic Parkinson's disease (PD)
is not known. In both disorders there is an extensive degeneration of serotonergic neurons …

Most of the genetically inherited Alzheimer's disease cases are caused by mutations in the
presenilin genes, PS1 and PS2. PS mutations result in the enhanced production of the …

The expression of the human presenilin-1 cellular gene is suppressed by the p53
protooncogene. The rapid kinetic of the down-regulation has suggested that it may result …

Senile plaques are neuropathological manifestations in Alzheimer's disease (AD) and are
composed mainly of extracellular deposits of amyloid β‐peptide (Aβ). Various data suggest …

Normal ageing and Alzheimer's disease (AD) have many features in common and, in many
respects, both conditions only differ by quantitative criteria. A variety of genetic, medical and …

Mutations in the presenilin-1 (PS-1) gene have been shown to cause early onset
Alzheimer's disease (EOAD) in an autosomal dominant manner. We have identified a novel …

Approximately 50% of familial Alzheimer's disease (AD) cases are linked to the presenilin
(PS) gene. This suggests that an altered function of mutated PSs accounts for a fundamental …

Accumulation of the amyloid-β (Aβ) peptide in the central nervous system (CNS) is
considered by many to be the crucial pathological insult that ultimately leads to the …

Objective: To present the clinical, neuroimaging, and electrophysiologic characteristics of a
variant AD phenotype. Background: The authors have identified a large Finnish kindred with …