Background Germline‐specific differential DNA methylation that persists through fertilization
and embryonic development is thought to be the 'imprint'distinguishing the parental alleles …

Differences in DNA methylation distinguish the maternal and paternal alleles of many
imprinted genes. Allele-specific methylation that is inherited from the gametes and …

The imprinted mouseH19gene is hypomethylated on the expressed maternal allele and
hypermethylated on the silent paternal allele. A 2-kb region of differential methylation …

DNA methylation differences between maternal and paternal alleles of many imprinted
genes are inherited from the male and female gametes and subsequently maintained during …

Genomic imprinting in mammals is controlled by DNA methylation imprints that are acquired
in the gametes, at essential sequence elements called 'imprinting control regions'(ICRs) …

The mouse H19 gene is imprinted so that the paternal copy is both methylated and
repressed during fetal development. However, the CpG-rich promoter region encompassing …

Genomic imprinting requires the differential marking by DNA methylation of genes in male
and female gametes. In the female germline, acquisition of methylation imprint marks …

Thousands of regions in gametes have opposing methylation profiles that are largely
resolved during the post-fertilization epigenetic reprogramming. However some specific …

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that
differ in male and female gametes at 'imprinting control regions'(ICRs). These marks mediate …

Only some imprinting control regions (ICRs) acquire their DNA methylation in the male germ
line. These imprints are protected against the global demethylation of the sperm genome …