The pivotal role in vivo of insulin is to control fuel homeostasis. Insulin exerts its effect on
three main target tissues: liver, fat and skeletal muscle. Resistance to the normal action of …

Insulin resistance of skeletal muscle, liver and fat combined with an abnormality of insulin
secretion characterizes Type 2 (non-insulin-dependent) diabetes mellitus. There is …

Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction
via protein phosphorylation cascades. Insulin action on signal transduction is impaired in …

Type II diabetes is characterized by defects in insulin action on peripheral tissues, such as
skeletal muscle, adipose tissue and liver and pancreatic β-cell defects. Since the skeletal …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

Introduction 3. Glucose transport regulation: Insulin signal transduction and GLUT4 vesicle
traffic 4. Defects in insulin signal transduction and GLUT4 translocation 5. Altered metabolic …

This review postulates and presents recent evidence that insulin resistance is initiated in the
adipose tissue and also suggests that the adipose tissue may play a pivotal role in the …

We summarize the existing literature data concerning the involvement of skeletal muscle
(SM) in whole body glucose homeostasis and the contribution of SM insulin resistance (IR) …

Type 2 diabetes is a polygenic disease characterized by defects in both insulin secretion
and insulin action. We have previously reported that isolated insulin resistance in muscle by …

Skeletal muscle is a major site of insulin resistance. In addition to glucose transport,
oxidative disposal and storage defects, insulin resistant muscle exhibit many other metabolic …