A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor

B Hu, QB Mei, XJ Yao, E Smith, WH Barry… - The FASEB …, 2001 - Wiley Online Library
The P2X4 receptor is a newly identified receptor expressed in the heart cell. Its function was
elucidated with cardiac transgenic (TG) expression of the receptor by using the myocardium …

Genomic structure, developmental distribution and functional properties of the chicken P2X5 receptor

A Ruppelt, W Ma, K Borchardt… - Journal of …, 2001 - Wiley Online Library
We report here the cloning of a chicken cDNA (402 aa) showing high sequence similarity to
the previously cloned rat and human P2X5 receptors (67 and 69%, respectively). The …

Activation-dependent changes in receptor distribution and dendritic morphology in hippocampal neurons expressing P2X2-green fluorescent protein receptors

BS Khakh, WB Smith, CS Chiu, D Ju… - Proceedings of the …, 2001 - National Acad Sciences
ATP-gated P2X2 receptors are widely expressed in neurons, but the cellular effects of
receptor activation are unclear. We engineered functional green fluorescent protein (GFP) …

Developmental expression of metabotropic P2Y1 and P2Y2 receptors in freshly isolated astrocytes from rat hippocampus

Y Zhu, HK Kimelberg - Journal of neurochemistry, 2001 - Wiley Online Library
There are at least three subtypes of cloned metabotropic P2 receptors linked to intracellular
Ca2+ rises in rat brain cells, namely, P2Y1, P2Y2 and P2Y4. In this study we explore the …

Changes in P2X receptor responses of sensory neurons from P2X3‐deficient mice

Y Zhong, PM Dunn, M Bardini… - European Journal of …, 2001 - Wiley Online Library
Dorsal root ganglion (DRG) neurons respond to ATP with transient, persistent or biphasic
inward currents. In contrast, the ATP responses in nodose neurons are persistent. These …

Diadenosine polyphosphates as extracellular signal molecules

CHV Hoyle, RH Hilderman, JJ Pintor… - Drug development …, 2001 - Wiley Online Library
Dinucleoside polyphosphates are an interesting group of signalling molecules that control
numerous physiological functions. Diadenosine compounds, with a backbone of anything …

Expression of nucleotide P2X receptor subtypes during spermatogenesis in the adult rat testis

R Glass, M Bardini, T Robson, G Burnstock - Cells Tissues Organs, 2001 - karger.com
The expression of ATP-gated ion channels (P2X receptors) was investigated in testes of
adult rats by immunohistochemistry and Western blotting with antibodies against all seven …

Evidence for the involvement of purinergic signalling in the control of respiration

T Thomas, V Ralevic, M Bardini, G Burnstock… - Neuroscience, 2001 - Elsevier
The ventrolateral medulla has a critical role in the generation and patterning of respiration
via an extensive network of respiratory neurones. We have investigated the effects of …

Depletion of substance P from rat primary sensory neurons by ATP, an implication of P2X receptor-mediated release of substance P

T Nakatsuka, N Mena, J Ling, JG Gu - Neuroscience, 2001 - Elsevier
Effects of ATP on substance P immunoreactivity were examined in cultured dorsal root
ganglion neurons. We found that treatment of dorsal root ganglion neurons with ATP …

Multiple P2X receptors on guinea‐pig pelvic ganglion neurons exhibit novel pharmacological properties

Y Zhong, PM Dunn, G Burnstock - British journal of …, 2001 - Wiley Online Library
Application of ATP and α, β‐methylene ATP (αβmeATP) to voltage‐clamped guinea‐pig
pelvic neurons produced three types of inward currents. A fast‐desensitizing response was …