Next to a profound T cell immunodeficiency, HIV-1 infection induces activation and
dysfunction of B cells, resulting in hypergammaglobulinemia. Whereas T cell immune …

We studied how combination antiviral therapy affects B cell abnormalities associated with
HIV-1 infection, namely elevated circulating immunoglobulin (Ig) G antibody-secreting cell …

Background: Some immune defects caused by HIV infection resolve following treatment with
highly active antiretroviral therapy (HAART), but residual immune dysfunction may cause …

Today's antiretroviral combination regimens can induce significant and sustained decreases
in human immunodeficiency virus (HIV)-RNA levels, allowing the immune system to recover …

Progressive immune deficiency arising during HIV disease reflects the continual
degradation and the ultimate deletion of immune specificites defined by the CD4+ T …

Immune reconstitution during antiretroviral therapy has recently been shown to depend
upon multiple factors at work in T cell homeostasis, amongst which the reduction of thymus …

Hypergammaglobulinemia and defective humoral immunity are hallmarks of HIV-1 infection.
Naive B cells have been recently suggested as the major source of …

The course of human immunodeficiency virus (HIV) disease is characterized by a
progressive decline in immune function. The advent of highly active antiretroviral therapy …

Background: Current antiretroviral treatment can induce significant and sustained virological
and immunological responses in HIV-1-infected persons over at least the short-to mid-term …

Objectives: To review the current understanding of the details and mechanisms of immune
restoration that follows administration of suppressive antiretroviral therapies to persons with …