Summary Background Background Activated microglia have a key role in the brain's
immune response to neuronal degeneration. The transition of microglia from the normal …

Microglia constitute the primary resident immune surveillance cell in the brain and are
thought to play a significant role in the pathogenesis of several neurodegenerative …

Using positron emission tomography and [11C](R)‐PK11195, a marker of “peripheral
benzodiazepine sites” that is upregulated on activated microglia during progressive tissue …

Chronic microglial activation is an important component of many neurological disorders, and
imaging activated microglia in vivo will enable the detection and improved treatment of …

Healthy brain aging is characterized by neuronal loss and decline of cognitive function.
Neuronal loss is closely associated with microglial activation and postmortem studies have …

Activated microglia are involved in the immune response of multiple sclerosis (MS). The
peripheral benzodiazepine receptor (PBR) is expressed on microglia and up‐regulated after …

Activated microglia may promote neurodegeneration in Alzheimer's disease (AD) and may
also help in amyloid clearance in immunization therapies. In vivo imaging of activated …

Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease - The
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Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

BACKGROUND: Reactive microgliosis, hallmark of neuroinflammation, may contribute to
neuronal degeneration, as shown in several neurodegenerative diseases. We in vivo …