The last ten years have witnessed major advances in our understanding of zinc transporters
and their regulation in eukaryotic organisms. Two families of transporters, the ZIP (Zrt-, I rt …

In recent years, a number of mammalian zinc transporters have been identified, and
candidate genes are rapidly growing. These transporters are classified into two families: ZIP …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

▪ Abstract New insights into mammalian zinc metabolism have been acquired through the
identification and characterization of zinc transporters. These proteins all have …

Genes that are involved in mammalian zinc transport recently have been cloned. These all
predict proteins with multiple membrane spanning regions, and most have a histidine-rich …

Structural, catalytic, and regulatory functions of zinc in biology continue to be defined. The
number of genes coding for proteins with zinc-binding domains is conservatively estimated …

Zinc is an essential metal for all eukaryotes, and cells have evolved a complex system of
proteins to maintain the precise balance of zinc uptake, intracellular storage, and efflux. In …

Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian
proteins and can modulate the function of many others. Because of the pleiotropic effects of …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

The yeast Saccharomyces cerevisiae has two separate systems for zinc uptake. One system
has high affinity for substrate and is induced in zinc-deficient cells. The second system has …