KCNQ genes encode a growing family of six transmembrane domains, single pore-loop, K+
channel α-subunits that have a wide range of physiological correlates. KCNQ1 (KvLTQ1) is …

Humans have over 70 potassium channel genes, but only some of these have been linked
to disease. In this respect, the KCNQ family of potassium channels is exceptional: mutations …

Mutations in all four known KCNQ potassium channel α-subunit genes lead to human
diseases,,,,,. KCNQ1 (KvLQT1) interacts with the β-subunit KCNE1 (IsK, minK) to form the …

The KCNQ family of K+ channels has been implicated in several cardiac and neurological
disease pathologies. KCNQ2 (Q2) is a brain-derived gene, which in association with KCNQ3 …

Potassium channels regulate electrical signaling and the ionic composition of biological
fluids. Mutations in the three known genes of the KCNQ branch of the K+ channel gene …

Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant
form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been …

Benign familial neonatal convulsions (BFNC), a class of idiopathic generalized epilepsy, is
an autosomal dominantly inherited disorder of newborns. BFNC has been linked to …

Mutations in KCNQ K+ channel genes underlie several human pathologies. KCNQ α‐
subunits form either homotetramers or hetero‐oligomers with a restricted subset of other …

KCNQ1 α-subunits coassemble with KCNE1 β-subunits to form channels that conduct the
slow delayed rectifier K+ current (I Ks) important for repolarization of the cardiac action …

We have isolated KCNQ5, a novel human member of the KCNQ potassium channel gene
family that is differentially expressed in subregions of the brain and in skeletal muscle. When …