ATP is found in every cell, where it is a major source of energy. But in the nervous system,
ATP also has additional actions, which include its role in fast synaptic transmission and …

This article reviews the extent to which recent studies substantiate the hypothesis that ATP
functions as a peripheral pain mediator. The discovery of the P2X family of ion channels (for …

Increasing evidence indicates the importance of extracellular adenosine triphosphate (ATP)
in the modulation of neuronal function. In particular, fine control of ATP release and the …

A role for ATP in nociception and pain induction was proposed on the basis of human
psychophysical experiments shortly after the formulation of the purinergic hypothesis …

The understanding of how pain is processed at each stage in the peripheral and central
nervous system is the precondition to develop new therapies for the selective treatment of …

In 1995 the P2X3 receptor was found to be expressed at high levels in nociceptive sensory
neurones, consistent with earlier reports that ATP induced pain in humans and animals. At …

ATP acts as a fast neurotransmitter by activating a family of ligand-gated ion channels, the
P2X receptors. Functional homomeric (P2X3) and heteromeric (P2X2/3) receptors are highly …

Enhanced sensitivity to noxious stimuli and the perception of non-noxious stimuli as painful
are hallmark sensory perturbations associated with chronic pain. It is now appreciated that …

The potential importance for nociception of P2X receptors, the ionotropic receptors activated
by ATP, is underscored by the variety of pain states in which this endogenous ligand can be …

There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in
autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but …