The ionotropic ATP receptor subunits P2X1–6 receptors play important roles in synaptic
transmission, yet the P2X7receptor has been reported as absent from neurons in the normal …

Abstract ATP stimulates [Ca 2+] i increases in midbrain synaptosomes via specific ionotropic
receptors (P2X receptors). Previous studies have demonstrated the implication of P2X 3 …

The proposed presence of P2X7 receptor (P2X7R) in neurons has been the source of some
contention. Initial studies suggested an absence of P2X7R mRNA in neurons, and the …

P2X7 receptor is a member of the P2X family of ATP-gated ion channels. The cellular
localization of P2X7 receptors in the central nervous system remains controversial because …

P2X7 receptors are ligand-gated ion channels, expressed as homo-oligomeric assemblies
of individual subunits. They are widely distributed at immunocompetent cells of the central …

Among seven members of P2X ionotropic receptors activated by extracellular ATP, the P2X7
subtype is unique in that it can function as a cation channel, a nonselective pore, or even a …

The presence of ionotropic P2X7 receptor has been studied in mice brain from wild type and
P2X7 receptor knockout animals. Western blot and immunocytochemical assays show the …

Ligand-gated ion channels are prototypic oligomeric membrane proteins whose
stoichiometry determines their functional properties and subcellular localization …

Extracellular ATP exerts pronounced biological actions in virtually every organ or tissue that
has been studied. In the central and peripheral nervous system, ATP acts as a fast excitatory …

Presynaptic P2X7 receptors are thought to play a role in the modulation of transmitter
release and have been localised to terminals with the location and morphology typical of …