The constitutive expression of angiogenic and tumorigenic chemokines by tumour cells
facilitates the growth of tumours. The transcription of these angiogenic and tumorigenic …

Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …

The nf‐kb2 gene encodes the cytoplasmic NF‐κB inhibitory protein p100 from which the
active p52 NF‐κB subunit is derived by proteasome‐mediated proteolysis. Ligands which …

The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors:
TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the …

Protein modification via covalent attachment of ubiquitin has emerged as one of the most
common regulatory processes in all eukaryotes; it is possibly second only to …

NF-κB is a transcription factor that is critical for innate and adaptive immunity. Recently, a
noncanonical pathway for NF-κB activation has emerged. Four recent papers provide …

Extracellular stimuli signal for activation of the transcription factor NFκB, leading to gene
expression regulating processes involved in immune responses, inflammation, and cell …

There are several well-charac-terized signaling pathways and transcription factors that are
likely to be involved in critical diseases. Of these, the IKK/NF-κB pathway might play an …

Chemotherapeutic agents simultaneously induce transcription factors p53 and NFκB. p53
induction can activate an apoptotic program, and resistance to chemotherapy correlates with …

NF-κB signaling is required for the maintenance of normal B lymphocytes, whereas
dysregulated NF-κB activation contributes to B cell lymphomas. The events that regulate NF …