TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-κB activation and IL-10 production

LG Xu, HB Shu - The Journal of Immunology, 2002 - journals.aai.org
TALL-1 is a member of the TNF family that is critically involved in B cell survival, maturation,
and progression of lupus-like autoimmune diseases. TALL-1 has three receptors, including …

[HTML][HTML] Signaling for survival and apoptosis in the immune system

TW Mak, WC Yeh - Arthritis Research & Therapy, 2002 - Springer
Chapter summary Signal transduction induced by tumor necrosis factor (TNF) family
members and their receptors has been an intensive area of research for several years. The …

[HTML][HTML] Genetic evidence for the essential role of β-transducin repeat-containing protein in the inducible processing of NF-κB2/p100

A Fong, SC Sun - Journal of Biological Chemistry, 2002 - ASBMB
Processing of the nfκb2gene product p100 to generate p52 is an important step in NF-κB
regulation. This step is regulated by a nonclassical NF-κB signaling pathway involving the …

Requirement for the NF-κB family member RelA in the development of secondary lymphoid organs

E Alcamo, N Hacohen, LC Schulte… - The Journal of …, 2002 - rupress.org
The transcription factor nuclear factor (NF)-κB has been suggested to be a key mediator of
the development of lymph nodes and Peyer's patches. However, targeted deletion of NF …

Identification of signal transduction pathways involved in constitutive NF-κB activation in breast cancer cells

P Bhat-Nakshatri, CJ Sweeney, H Nakshatri - Oncogene, 2002 - nature.com
Nuclear factor-κB (NF-κB) is usually maintained in an inactive form in the cytoplasm through
its association with inhibitor of kappaB (IκB) proteins, and is activated upon stimulation of …

[HTML][HTML] RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation

PM Holland, CR Willis, S Kanaly, MB Glaccum… - Current Biology, 2002 - cell.com
The epidermis is a stratified, continually renewing epithelium dependent on a balance
among cell proliferation, differentiation, and death for homeostasis. In normal epidermis, a …

Regulation of the immune system by NF-κB and IκB

HC Liou - BMB reports, 2002 - koreascience.kr
Abstract NF-${\kappa} B $/Rel transcription factor family participates in diverse biological
processes including embryo development, hematopoiesis, immune regulation, as well as …

Regulation of B cell fates by BCR signaling components

T Kurosaki - Current opinion in immunology, 2002 - Elsevier
Recent results obtained in mice harboring cytoplasmic mutations of Igα and/or Igβ have
reinforced the concept that the strength of BCR signaling is important for ensuring …

NF-κB and breast cancer

H Nakshatri, RJ Goulet Jr - Current problems in cancer, 2002 - Elsevier
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[HTML][HTML] The NEDD8 pathway is essential for SCFβ-TrCP-mediated ubiquitination and processing of the NF-κB precursor p105

RE Amir, K Iwai, A Ciechanover - Journal of Biological Chemistry, 2002 - ASBMB
The p50 subunit of NF-κB is generated by limited processing of the precursor p105. IκB
kinase-mediated phosphorylation of the C-terminal domain of p105 recruits the SCF β-TrCP …