Background & Aims: Nuclear factor (NF) κB1, NF-κB2, and Bcl-3 encode for proteins of the
NF-κB/Rel/IκB families, known as regulators of innate and adoptive immune responses …

Lymphotoxin-β receptor (LTβR) is a member of the tumor necrosis factor receptor (TNFR)
superfamily that activates nuclear factor-κB (NF-κB) through the IκB kinase (IKK) complex …

IκB kinase γ (IKKγ)(also known as NEMO, Fip-3, and IKKAP-1) is the essential regulatory
component of the IKK complex; it is required for NF-κB activation by various stimuli, including …

NF-κB is a transcription factor governing the expression of genes involved in the immune
response, embryo or cell lineage development, cell apoptosis, cell cycle progression …

The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of
a number of early response genes associated with inflammatory responses, cell growth, cell …

Nuclear factor-kappa-B (NF-κB) is considered a central mediator of the immune response.
Well over 100 genes are activated by this transcription factor and most of them are directly or …

Nuclear factor-κB (NF-κB) promotes cell survival by upregulating expression of anti-
apoptotic genes, a process that is antagonized by inhibitors of κB (IκB) factors. The only NF …

Stimulation of cells with tumor necrosis factor α (TNFα) triggers NF-κB1 p105 proteolysis,
releasing associated Rel subunits to translocate into the nucleus and modulate target gene …

Chapter summary Signals emanating from receptors of the tumor necrosis factor/nerve
growth factor (TNF/NGF) family control practically all aspects of immune defense and, as …

Transcription factor NF-κB has been implicated in cancer development due to its ability to
upregulate expression of genes with potentially prooncogenic functions, such as cell cycle …