NF-κB is a transcription factor that regulates a variety of genes involved in the control of the
immune and inflammatory responses. Activation of NF-κB is mediated by an inducible I-κB …

Caspases are instrumental in the implementation of apoptotic cell death, and caspase
activation is in most investigated cases closely linked to apoptosis. Recent data …

Proteasome-mediated processing of thenfκb2 gene product p100 is a regulated event that
generates the NF-κB subunit p52. This event can be induced through p100 phosphorylation …

The NF-κB proteins are critical in the regulation of the immune and inflammatory response.
Stimulation of the NF-κB pathway leads to increases in I-κB kinase β (IKKβ) kinase activity to …

Aberrant gene expression is a primary cause of many disease-associated
pathophysiologies. Therefore, the pharmacological modulation of transcription factor activity …

Endothelial activation induces expression of pro-inflammatory molecules that are thought to
play an important role in atherogenesis through enhanced vascular monocyte recruitment …

We review our current understanding of the molecular determinants and mechanisms of
lymphocyte apoptosis and identify the key regulators of these death-signaling pathways. In …

The transcription factor NF-κB exhibits altered activity in some breast cancers but the
relevance of this association has not been established. Cao et al.'s elegant study recently …

The cells constituting each organ system of the body are continuously challenged by an
array of endocrine, paracrine and autocrine agonists which ensure the maintenance of …

To search for negative regulatory components of the NF‐κB activation pathways, we
mutagenized Rat‐1 fibroblasts and established a stable mutant cell line with a constitutive …