The inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are
overexpressed in colonic tumors of humans, as well as in colon tumors that develop in rats …

Genetic and pharmacological evidence suggests that overexpression of cyclooxygenase-2
(COX-2) is critical for epithelial carcinogenesis and provides a major target for cancer …

Both nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX) 2-selective
inhibitors such as celecoxib are being reported as having potent anticancer activity in …

To understand the potential role of cyclooxygenase (COX) in normal and inflammatory
human diseases, we characterized the expression of COX-1 and COX-2 in biopsies of …

Inducible nitric oxide synthase (iNOS) content is elevated in human lung adenocarcinomas,
and lung cancer patients exhale more nitric oxide (NO) than healthy individuals. The …

The effect of selective and non-selective cyclo-oxygenase inhibition on tumour growth and
metastasis in an orthotopic model of breast cancer was investigated. 4T1 mammary …

Malignant mesothelioma (MM) is a fatal tumor of increasing incidence, which is resistant to
current therapy. Cyclooxygenase-2 (COX-2) plays an important role in solid tumor growth …

The presence of multiple drug resistance (MDR1) and angiogenic phenotypes negatively
affect patients' prognosis with cancer even when treated with drugs that are not transported …

Laminin-5 is an extracellular matrix protein that plays a key role in cell migration and tumor
invasion. Cox-2 is an induced isoform of cyclooxygenases that plays an important role in …

In addition to their proinflammatory activities, prostaglandins recently have been shown to
be beneficial in the resolution of tissue injury and inflammation. Thus, inhibition of …