At the dawn of this new century, cancer prevention has become a new frontier for cancer
research. Science and technology have evolved sufficiently to consider using our …

The present study involved the in vivo evaluation of orally administered guar gum-based
colon-targeted tablet formulations of celecoxib (colon-targeted tablet-20 or colon-targeted …

Colorectal cancer (CRC) accounts for nearly 12% of newly diagnosed cancers in the United
States and is the second leading cause of cancer deaths (1, 2). Multidisciplinary research in …

Colorectal cancer is the second leading cause of cancer death in Western countries. If
surgery remains the only cure, recurrence rates for colon cancer range from 30% to 60% for …

A seminal advance in the prevention of colon cancer has been the observation that
nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of and mortality from …

目的: 观察COX-2 在急性肝损伤中的表达, 探讨COX-2 与急性肝损伤的关系. 方法: 将50 只♂
Wistar 大鼠随机分为正常组10 只, 对照组10 只腹腔注射CCL4 原液1mL· kg-1, 实验组30 只分3 …

The expression of COX-2 participates strongly in polyp formation of adenomatous polyposis
coli (APC)-mutated mice. However, the mechanism of growth inhibition by COX-2 inhibition …

Colorectal cancer, one of the most common and persistent human malignancies in the
Western world, accounts for about 57,000 deaths annually in the United States (1, 2); and …

The hypothesis that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) might
protect against colorectal, and possibly other cancers, arose in the mid-1970s when higher …

Despite significant progress in understanding the molecular basis of colorectal cancer, the
disease remains a major global health problem that leads to approx 550, 00 annual deaths …