The angiopoietin family of secreted factors is functionally defined by the C-terminal
fibrinogen (FBN)-like domain, which mediates binding to the Tie2 receptor and thereby …

Objectives—Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein that has recently
been implicated in the regulation of angiogenesis and metastasis. This study aimed to …

A general understanding of the molecular mechanisms underlying angiogenesis is
emerging from the analysis of targeted mutations in vasculature-related genes. These …

Vascular network formation requires several endothelial cell growth factors. These factors
have a potent angiogenic effect, and their precise coordination is essential for vascular …

Angiopoietin-like 4 (ANGPTL4), a secreted protein of the angiopoietin-like family, is induced
by hypoxia in both tumor and endothelial cells as well as in hypoxic perinecrotic areas of …

Angiopoietin-like protein (Angptl) 1 and Angptl2, which are considered orphan ligands, are
highly homologous, particularly in the fibrinogen-like domain containing the putative …

Angiopoietin-like (ANGPTL) proteins are secreted proteins showing structural similarity to
members of the angiopoietin family. Some ANGPTL proteins possess pleiotropic activities …

Angiopoietin-like 4 (ANGPTL4) is a secreted protein that belongs to the angiopoietin family
and is involved in angiogenesis and metabolism regulation. We previously reported the …

Angiopoietin-like protein 4 (Angptl4) is a recently identified circulating protein expressed
primarily in adipose tissue and liver. Also known as peroxisome proliferator-activated …

Recently, a family of proteins structurally similar to the angiogenic regulating factors
angiopoietins was identified and designated “angiopoietin-like proteins”(Angptls). Encoded …