To identify genes influencing age at onset (AAO) in two common neurodegenerative
diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; …

We performed an affected sib‐pair (ASP) linkage analysis to test for the effects of age at
onset (AAO), rate of decline (ROD), and Apolipoprotein E (APOE) genotype on linkage to …

Although it is clear that apoE plays an important role in the genetics of late-onset Alzheimer
disease (AD), evidence exists that additional genes may play a role in AD, and estimates of …

Objectives To determine the genetic contribution to non–autosomal dominant early-onset
Alzheimer disease (EOAD)(onset age≤ 60 years) cases and identify the likely mechanism …

Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and
the most common form of dementia in the elderly. It is a complex disorder with environmental …

We previously reported genetic linkage of loci controlling age-at-onset in Alzheimer disease
(AD) and Parkinson's disease (PD) to a 15 cM region on chromosome 10q. Given the large …

Four genes affecting Alzheimer's Disease (AD)(AP, PS1, PS2, and APOE) have been
identified and a fifth potential gene localized to chromosome 12. Collectively, these genes …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four
genes have been established to either cause early-onset autosomal-dominant AD (APP …

Alzheimer's disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease‐altering treatments. It is a complex disorder …

Importance BecauseAPOElocus variants contribute to risk of late-onset Alzheimer disease
(LOAD) and to differences in age at onset (AAO), it is important to know whether other …