Age at onset in two common neurodegenerative diseases is genetically controlled
To identify genes influencing age at onset (AAO) in two common neurodegenerative
diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; …
diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; …
Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease
P Holmans, M Hamshere… - American Journal of …, 2005 - Wiley Online Library
We performed an affected sib‐pair (ASP) linkage analysis to test for the effects of age at
onset (AAO), rate of decline (ROD), and Apolipoprotein E (APOE) genotype on linkage to …
onset (AAO), rate of decline (ROD), and Apolipoprotein E (APOE) genotype on linkage to …
The number of trait loci in late-onset Alzheimer disease
EW Daw, H Payami, EJ Nemens, D Nochlin… - The American Journal of …, 2000 - cell.com
Although it is clear that apoE plays an important role in the genetics of late-onset Alzheimer
disease (AD), evidence exists that additional genes may play a role in AD, and estimates of …
disease (AD), evidence exists that additional genes may play a role in AD, and estimates of …
Autosomal recessive causes likely in early-onset Alzheimer disease
Objectives To determine the genetic contribution to non–autosomal dominant early-onset
Alzheimer disease (EOAD)(onset age≤ 60 years) cases and identify the likely mechanism …
Alzheimer disease (EOAD)(onset age≤ 60 years) cases and identify the likely mechanism …
Clinical genetics of Alzheimer's disease
Z Zou, C Liu, C Che, H Huang - BioMed research international, 2014 - Wiley Online Library
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and
the most common form of dementia in the elderly. It is a complex disorder with environmental …
the most common form of dementia in the elderly. It is a complex disorder with environmental …
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
We previously reported genetic linkage of loci controlling age-at-onset in Alzheimer disease
(AD) and Parkinson's disease (PD) to a 15 cM region on chromosome 10q. Given the large …
(AD) and Parkinson's disease (PD) to a 15 cM region on chromosome 10q. Given the large …
Identification of novel genes in late-onset Alzheimer's disease
MA Pericak-Vance, J Grubber, LR Bailey… - Experimental …, 2000 - Elsevier
Four genes affecting Alzheimer's Disease (AD)(AP, PS1, PS2, and APOE) have been
identified and a fifth potential gene localized to chromosome 12. Collectively, these genes …
identified and a fifth potential gene localized to chromosome 12. Collectively, these genes …
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. To date four
genes have been established to either cause early-onset autosomal-dominant AD (APP …
genes have been established to either cause early-onset autosomal-dominant AD (APP …
Genetics of Alzheimer's disease
PG Ridge, MTW Ebbert… - BioMed research …, 2013 - Wiley Online Library
Alzheimer's disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease‐altering treatments. It is a complex disorder …
death in the United States that lacks disease‐altering treatments. It is a complex disorder …
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study
Importance BecauseAPOElocus variants contribute to risk of late-onset Alzheimer disease
(LOAD) and to differences in age at onset (AAO), it is important to know whether other …
(LOAD) and to differences in age at onset (AAO), it is important to know whether other …