The transcription factor C/EBPα is crucial for the differentiation of granulocytes. Conditional
expression of C/EBPα triggers neutrophilic differentiation, and C/EBPα can block 12-O …

C/EBPα and PU. 1 are key regulators of early myeloid development. Mice lacking C/EBPα or
PU. 1 have reduced granulocytes and monocytes. Consistent with a model in which …

CCAAT/enhancer binding protein α (C/EBPα)-ER induces 32Dcl3 neutrophilic differentiation
and inhibits 32DPKCδ maturation to macrophages in response to phorbol ester. In 32Dcl3 …

CCAAT/enhancer-binding protein α (C/EBPα) is one of the key transcription factors that
mediate lineage specification and differentiation of multipotent myeloid progenitors into …

The transcription factor CCAAT/enhancer binding protein α (C/EBPα) regulates a number of
myeloid cell-specific genes. To delineate the role of C/EBPα in human granulopoiesis, we …

PU. 1 directs the hematopoietic stem cell to the lymphoid-myeloid progenitor (LMP) and
interacts with GATA-binding protein 1 to inhibit commitment to the megakaryocyte-erythroid …

Several transcription factors have been implicated as playing a role in myelopoiesis. PU. 1,
an ets-family transcription factor, is required for the development of myeloid and lymphoid …

CCAAT/enhancer binding protein α (C/EBPα) is an integral factor in the granulocytic
developmental pathway, as myeloblasts from C/EBPα-null mice exhibit an early block in …

The CCAAT/enhancer binding protein-α (C/EBPα) is a transcription factor required for
differentiation of myeloid progenitors. In addition to specific DNA binding, C/EBPα is also …

C/EBPα is required for generation of granulocyte-monocyte progenitors, but the subsequent
role of C/EBPα in myeloid lineage commitment remains uncertain. We transduced murine …