Gene delivery to target tissues is often limited by the native tropism of the viral or non-viral
vector used. Failure to infect the target cell of choice may limit the use of an otherwise …

Recombinant adenovirus vectors (Ad) have been recognized as effective in vivo gene
delivery vehicles and utilized as gene therapy agents for a number of cancers. The …

The success of gene therapy depends on the specificity of transgene delivery by therapeutic
vectors. The present study describes the use of an adenovirus (Ad) fiber replacement …

In addition to its classical CD40 receptor, CD154 also binds to αIIbβ3, α5β1, and αMβ2
integrins. Binding of CD154 to these receptors seems to play a key role in the pathogenic …

CD151, one of the tetraspanins, forms a stable complex with integrin α3β1, the major laminin
receptor on the cell surface. We found that 8C3, an anti-CD151 mAb obtained by screening …

The use of immune plasmid adjuvants encoding cytokine, chemokine or immune modulators
to tailor the vaccine induced response is a strength of DNA vaccine approaches. This has …

Fibronectin is an extracellular matrix protein with broad binding specificity to cell surface
receptors, integrins. The tenth fibronectin type III domain (FNfn10) is a small, autonomous …

Background Retargeting is necessary to overcome the limitations of adenovirus (Ad)‐based
gene therapy vectors. To this end, we previously constructed an adenovirus with the fiber …

The engineering of either complete virus cell-binding proteins or derived ligand peptides
generates promising nonviral vectors for cell targeting and gene therapy. In this work, we …

Interactions between CD40 and CD40 ligand (CD154) are essential in the regulation of both
humoral and cellular immune responses. Forced expression of human CD154 in B chronic …