More than half of all chronic cancer pain arises from metastases to bone, and bone cancer
pain is one of the most difficult of all persistent pain states to fully control. Several tumor …

Chronic pain resulting from metastatic bone cancer remains poorly understood and resistant
to treatment. Here we have examined the effect of the novel COX-2 enzyme inhibitor …

Abstract Cyclooxygenase-2 (COX-2), the rate-limiting enzyme of prostaglandin synthesis,
has been implicated in invasiveness and distant metastases of cancer. Bone is one of the …

NON-STEROIDAL ANTI-INFLAMMATORY drugs (NSAIDs) are among the most commonly
prescribed drugs worldwide. Indicated in the treatment of several forms of arthritis, menstrual …

Cyclooxygenase (COX) catalyzes the initial step of arachidonic acid metabolism and
prostaglandin production. COX activity has been found to be associated with 2 distinct …

We previously reported that mouse mammary carcinoma cell lines (MMT060562 and BALB/c‐
MC) induced osteoclast formation through production of prostaglandin E2 (PGE2) in …

Cyclooxygenase-2 (COX-2) is an enzyme induced by a variety of factors including tumor
promoters, cytokines, growth factors and hypoxia. It is involved in the metabolic conversion …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Nearly 30 years ago, cyclooxygenase (COX) was identified as an enzyme that initiates the
biotransformation of arachidonic acid to prostanoids. It is now known that COX exists as two …

Although bone cancer pain can be severe and is relatively common, very little is known
about the basic mechanisms that generate and maintain this debilitating pain. To begin to …