The lymphotoxin-β receptor (LTβR) plays critical roles in inflammation and lymphoid
organogenesis through activation of NF-κB. In addition to activation of the classical NF-κB …

NF-κB-inducing kinase (NIK) has been shown to play an essential role in the NF-κB
activation cascade elicited by lymphotoxin β receptor (LTβR) signaling. However, the …

Recent studies revealed that the lymphotoxin/lymphotoxin beta receptor (LT)/LTβR system
activates the noncanonical nuclear factor-κB (NF-κB) signaling pathway involving I kappa B …

Lymphotoxin ॆ receptor (LTॆR)-induced activation of NF-κB in mouse embryo fibroblasts
was mediated by the classical pathway and by an alternative or second pathway. The …

IκB Kinase (IKK) α is required for activation of an alternative NF‐κB signaling pathway based
on processing of the NF‐κB2/p100 precursor protein, which associates with RelB in the …

Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes,
including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the …

Tumor necrosis factor-α (TNF-α) and lymphotoxin-β receptor (LTβR) signaling both play
important roles in inflammatory and immune responses through activation of NF-κB. Using …

Both nuclear factor (NF)-κB–inducing kinase (NIK) and inhibitor of κB (IκB) kinase (IKK) have
been implicated as essential components for NF-κB activation in response to many external …

The 'classical'NF‐κB activation pathway proceeds via IκB kinase (IKK)‐β/γ‐mediated
phosphorylation, induced ubiquitination and the degradation of small IκBs. An alternative …

The transcription factor NF-κB is of major importance in the biology of pro-inflammatory
cytokines, such as TNF-α and IL-1α, and thereby is intimately involved in the process of …