Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR)
signals to make crucial cell-fate decisions at several checkpoints during their development …

B‐cell development is a highly ordered multistep process dependent upon signals
generated by the pre‐B and B‐cell antigen receptor (BCR). BCR signals drive maturation of …

Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways
have been described in extraordinary molecular detail, mainly from studies of B cell …

Signalling through the B‐cell antigen receptor (BCR) is required throughout B‐cell
development and peripheral maturation. Targeted disruption of BCR components or …

B-cell development is characterized by a number of tightly regulated selection processes.
Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation …

B cell receptors (BCRs) generate tonic signals critical for B cell survival and early B cell
development. To determine whether these signals also mediate the development of …

Signaling through the B cell receptor (BCR) plays a critical role at multiple checkpoints of B
cell biology. BCR acts as a gatekeeper of the progression of their early development in bone …

B cell Ag receptor (BCR) signaling changes dramatically during B cell development,
resulting in activation in mature B cells and apoptosis, receptor editing, or anergy in …

B cells are selected by the binding of antigen to clonally distributed B cell receptors (BCRs),
triggering signalling cascades that result in B cell activation. With the recent application of …

Signal transduction through the B cell antigen receptor (BCR) is determined by a balance of
positive and negative regulators. This balance is shifted by aggregation that results from …