Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers has spurred novel approaches to cancer …

Non-steroidal anti-inflammatory drugs (NSAIDs) have as their common mechanism the
inhibition of cyclooxygenase (COX) enzymes, of which two isoforms (COX-1 and COX-2) …

Increased prostaglandin (PG) production is associated with many inflammatory
pathophysiological conditions; it is derived from arachidonic acid by either of two enzymes …

Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …

The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors
of cyclooxygenase (COX) enzymes such as aspirin, inhibiting both COX‐1 and COX‐2 …

We comprehensively reviewed the published scientific literature on non-steroidal anti-
inflammatory drugs (NSAIDs) and cancer and evaluated results based upon epidemiologic …

Cyclooxygenase-2 (COX-2) is an enzyme induced by inflammatory and mitogenic stimuli
and results in enhanced synthesis of PGs in inflamed and neoplastic tissues. It is associated …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …