[HTML][HTML] Molecular basis for species-specific sensitivity to “hot” chili peppers
SE Jordt, D Julius - Cell, 2002 - cell.com
Chili peppers produce the pungent vanilloid compound capsaicin, which offers protection
from predatory mammals. Birds are indifferent to the pain-producing effects of capsaicin and …
from predatory mammals. Birds are indifferent to the pain-producing effects of capsaicin and …
[HTML][HTML] The cloned capsaicin receptor integrates multiple pain-producing stimuli
M Tominaga, MJ Caterina, AB Malmberg, TA Rosen… - Neuron, 1998 - cell.com
Capsaicin, the main pungent ingredient in" hot" chili peppers, elicits burning pain by
activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid …
activating specific (vanilloid) receptors on sensory nerve endings. The cloned vanilloid …
Vanilloid (Capsaicin) receptors and mechanisms
A Szallasi, PM Blumberg - Pharmacological reviews, 1999 - ASPET
With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …
The mysteries of capsaicin-sensitive afferents
A fundamental subdivision of nociceptive sensory neurons is named after their unique
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …
sensitivity to capsaicin, the pungent ingredient in hot chili peppers: these are the capsaicin …
Molecular cloning of an N-terminal splice variant of the capsaicin receptor: loss of N-terminal domain suggests functional divergence among capsaicin receptor …
MA Schumacher, I Moff, SP Sudanagunta… - Journal of Biological …, 2000 - ASBMB
Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to
encode an ion channel that is activated by both capsaicin, the pain producing compound in …
encode an ion channel that is activated by both capsaicin, the pain producing compound in …
The vanilloid receptor: a molecular gateway to the pain pathway
MJ Caterina, D Julius - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …
The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil
W Everaerts, M Gees, YA Alpizar, R Farre, C Leten… - Current Biology, 2011 - cell.com
Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental
models to induce pain and inflammation [1, 2]. The noxious effects of MO are currently …
models to induce pain and inflammation [1, 2]. The noxious effects of MO are currently …
A Nobel prize for sensational research
MJ Zylka - New England Journal of Medicine, 2021 - Mass Medical Soc
A Hot and Tactile Nobel Prize This year's Nobel Prize in Physiology or Medicine was
awarded to David Julius and Ardem Patapoutian for identifying molecules that relay …
awarded to David Julius and Ardem Patapoutian for identifying molecules that relay …
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
MJ Caterina, A Leffler, AB Malmberg, WJ Martin… - science, 2000 - science.org
The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory
neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid …
neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid …
TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate
T Iida, T Moriyama, K Kobata, A Morita, N Murayama… - …, 2003 - Elsevier
Capsiate is a capsaicin-like ingredient of a non-pungent cultivar of red pepper, CH-19
sweet. To elucidate the mechanisms underlying the non-pungency of capsiate, we …
sweet. To elucidate the mechanisms underlying the non-pungency of capsiate, we …