Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Several epidemiological, clinical and experimental studies established nonsteroidal anti-
inflammatory drugs (NSAIDs) as promising cancer chemopreventive agents. Long-term use …

According to WHO statistics, in 1996 875,000 new cases of colorectal cancer were
diagnosed and 495,000 deaths were attributed to it worldwide (1). It is the third most …

Non‐steroidal anti‐inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase
(COX)‐2, are therapeutic groups widely used for the treatment of pain, inflammation and …

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit colorectal carcinogenesis and
prevent or revert the growth of premalignant colonic polyps. They inhibit cyclooxygenase …

The possibility that non-steroidal anti-inflammatory drugs (NSAIDs) may have anti-
carcinogenic effects is derived from observations that many cancers overproduce …

Epidemiological studies suggest that aspirin and other nonsteroidal anti-inflammatory drugs
(NSAIDs) reduce the incidence of and mortality from colorectal, gastric, and esophageal …

Publisher Summary Several studies have shown that persons on a high fat diet with a
sedentary life-style have an increased risk for developing cancer of the large intestine, the …

▪ Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, appear to have
clinically significant anticarcinogenic effects in the gastrointestinal tract. Epidemiological …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …