P450-dependent arachidonic acid (AA) metabolites regulate arterial tone by modulating
calcium-activated (BK) potassium channels in vascular smooth muscle cells (VSMC) …

Epoxyeicosatrienoic acids (EETs) are cytochrome P450–derived metabolites of arachidonic
acid. They are potent endogenous vasodilator compounds produced by vascular cells, and …

Diets enriched in docosahexaenoic acid, a major n-3 fatty acid in fish oil, have hypotensive
properties. One mechanism that can lower blood pressure is the direct dilation of arterioles …

Cytochrome P450–derived epoxides of arachidonic acid [ie, the epoxyeicosatrienoic acids
(EETs)] are important lipid signaling molecules involved in the regulation of vascular tone …

Epoxyeicosatrienoic acids (EETs) are released from endothelial cells and potently dilate
small arteries by hyperpolarizing vascular myocytes. In the present study, we investigated …

5, 6-Epoxyeicosatrienoic acid (5, 6-EET) is a cytochrome P450 epoxygenase metabolite of
arachidonic acid that causes vasorelaxation. However, investigations of its role in biological …

Although epoxyeicosatrienoic acids, cytochrome P-450 mono-oxygenase metabolites of
arachidonic acid, have been demonstrated to play a crucial role in endothelial cell Ca2+ …

20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid (AA) metabolite
synthesized by cytochrome P-450 ω-oxidases, is reported to produce vasoconstriction in the …

Arachidonic acid can be oxidatively metabolized by cytochrome P450 epoxygenase to four
regioisomeric epoxyeichosatrienoic acids (5, 6-; 8, 9-; 11, 12-; 14, 15-EET), which exhibit …

Epoxyeicosatrienoic acids (EETs) are endothelium-derived arachidonic acid metabolites of
cytochrome P450. They dilate coronary arteries, open K+ channels, and hyperpolarize …