[图书][B] Mechanistic studies to elucidate the role of lipid vehicles on solubility, formulation and bioavailability of poorly soluble compounds

I Dumanli - 2002 - search.proquest.com
Lipids have been used to improve the bioavailability of poorly soluble drugs for almost
twenty years. However, they are still not well characterized. There are limited publications …

What determines drug solubility in lipid vehicles: is it predictable?

SS Rane, BD Anderson - Advanced drug delivery reviews, 2008 - Elsevier
Lipid-based drug delivery systems are of increasing interest to the pharmaceutical scientist
because of their potential to solubilize drug molecules that may be otherwise difficult to …

[HTML][HTML] Fundamental aspects of lipid-based excipients in lipid-based product development

D Nakmode, V Bhavana, P Thakor, J Madan, PK Singh… - Pharmaceutics, 2022 - mdpi.com
Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product
development. The use of lipids in designing formulations provides an opportunity to …

Lipid-based formulations for oral administration of poorly water-soluble drugs

H Mu, R Holm, A Müllertz - International journal of pharmaceutics, 2013 - Elsevier
Lipid-based drug delivery systems have shown great potentials in oral delivery of poorly
water-soluble drugs, primarily for lipophilic drugs, with several successfully marketed …

Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs

BK Nanjwade, DJ Patel, RA Udhani, FV Manvi - Scientia pharmaceutica, 2011 - mdpi.com
Lipid-based formulations encompass a diverse group of formulations with very different
physical appearance, ranging from simple triglyceride vehicles to more sophisticated …

Lipid–an emerging platform for oral delivery of drugs with poor bioavailability

S Chakraborty, D Shukla, B Mishra, S Singh - European journal of …, 2009 - Elsevier
The sole objective of pharmaceutical science is to design successful dosage forms which
fulfill the therapeutic needs of the patients effectively. Development of new drug entities is …

[HTML][HTML] Exploring LIPID's for their Potential to Improves bioavailability of lipophilic drugs candidates: a review

S Sambhakar, R Saharan, S Narwal, R Malik… - Saudi Pharmaceutical …, 2023 - Elsevier
This review aims to provide a thorough examination of the benefits, challenges, and
advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the …

Mechanisms of drug solubilization by polar lipids in biorelevant media

V Katev, Z Vinarov, S Tcholakova - European Journal of Pharmaceutical …, 2021 - Elsevier
Despite the widespread use of lipid excipients in both academic research and oral
formulation development, rational selection guidelines are still missing. In the current study …

Critical In Vitro Characterization Methods of Lipid-Based Formulations for Oral Delivery: a Comprehensive Review

NK Swarnakar, N Venkatesan, G Betageri - Aaps Pharmscitech, 2019 - Springer
Lipids have been extensively used in formulations to enhance dissolution and bioavailability
of poorly water-soluble as well as water-soluble drug molecules. The digestion of lipid …

[HTML][HTML] Recent advances in lipid-based formulation technology

CJH Porter, HD Williams, NL Trevaskis - Pharmaceutical research, 2013 - Springer
Lipid-based formulations encompass a wide variety of delivery modes and technologies,
ranging from immediate release to sustained release formulations, from liquids to semi …