Recent advances in genomics and proteomics, combined with the facilitated generation and
analysis of transgenic and gene-knockout animals, have revealed new complexities in …

The immunological roles of B-cells are being revealed as increasingly complex by functions
that are largely beyond their commitment to differentiate into plasma cells and produce …

It is now clear that functionally distinct subsets of mature peripheral B cells exist. Of these
subsets, marginal zone (MZ) B cells in the spleen are strategically positioned at the blood …

Marginal zone (MZ) B cells resemble fetally derived B1 B cells in their innate-like rapid
responses to bacterial pathogens, but the basis for this is unknown. We report that the MZ is …

To maintain the integrity of an organism constantly challenged by pathogens, the immune
system is endowed with a variety of cell types. B lymphocytes were initially thought to only …

Human marginal zone (MZ) B cells are, in a sense, a new entity. Although they share many
properties with their mouse counterpart, they also display striking differences, such as the …

Selection of recently formed B cells into the follicular or marginal zone (MZ) compartments is
proposed to occur by way of proliferative intermediates expressing high levels of CD21/35 …

Marginal zone (MZ) B cells comprise a subset of innate-like B cells found predominantly in
the spleen, but also in lymph nodes and blood. Their principal functions are participation in …

Using immunoglobulin heavy chain transgenic mice, we show that B cell clones reaching
the long-lived pool are heterogeneous: some are enriched in the CD21 high compartment …

B cells generate antibodies that are essential for immune protection, but their subgroups are
poorly defined. Here, we perform undirected deep profiling of B cells in matched human …