[HTML][HTML] Prostaglandin E2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line
XH Liu, A Kirschenbaum, M Lu, S Yao… - Journal of Biological …, 2002 - ASBMB
Hypoxia-induced up-regulation of vascular endothelial growth factor (VEGF) expression is a
critical event leading to tumor neovascularization. Hypoxia stimulates hypoxia-inducible …
critical event leading to tumor neovascularization. Hypoxia stimulates hypoxia-inducible …
NS398 reduces hypoxia‐inducible factor (HIF)‐1α and HIF‐1 activity: Multiple‐level effects involving cyclooxygenase‐2 dependent and independent mechanisms
H Zhong, M Willard, J Simons - International journal of cancer, 2004 - Wiley Online Library
Tissue hypoxia is a common feature in solid tumors. Hypoxia‐inducible factor 1 (HIF‐1) is a
critical transcription factor that regulates the expression of genes encoding factors that …
critical transcription factor that regulates the expression of genes encoding factors that …
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in …
Hypoxia stimulates a number of pathways critical to cancer cell survival, including the
activation of vascular endothelial growth factor (VEGF) transcription. In normal fibroblasts …
activation of vascular endothelial growth factor (VEGF) transcription. In normal fibroblasts …
[HTML][HTML] Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc
Y Mizukami, K Fujiki, EM Duerr, M Gala, WS Jo… - Journal of Biological …, 2006 - ASBMB
The induction of vascular endothelial growth factor (VEGF) is an essential feature of tumor
angiogenesis. Hypoxia is a potent stimulator of VEGF expression, and hypoxia-inducible …
angiogenesis. Hypoxia is a potent stimulator of VEGF expression, and hypoxia-inducible …
Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human …
XH Liu, A Kirschenbaum, S Yao, ME Stearns… - Clinical & experimental …, 1999 - Springer
Upregulation of vascular endothelial growth factor (VEGF) expression induced by hypoxia is
crucial event leading to neovascularization. Cyclooxygenase-2, an inducible enzyme that …
crucial event leading to neovascularization. Cyclooxygenase-2, an inducible enzyme that …
Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer
P Büchler, HA Reber, M Büchler, S Shrinkante… - Pancreas, 2003 - journals.lww.com
Aims To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by
hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor …
hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor …
Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian …
MCA Duyndam, MPA van Berkel, JC Dorsman… - Biochemical …, 2007 - Elsevier
Vascular Endothelial Growth Factor (VEGF) and its transcriptional regulator Hypoxia-
inducible Factor 1 (HIF-1) play an important role in the process of angiogenesis in many …
inducible Factor 1 (HIF-1) play an important role in the process of angiogenesis in many …
Hypoxia inducible factor‐1α/vascular endothelial growth factor signaling activation correlates with response to radiotherapy and its inhibition reduces hypoxia …
H Zhu, S Zhang - Journal of cellular biochemistry, 2018 - Wiley Online Library
Like other tumors, lung cancer must induce angiogenesis as it grows. Hypoxia‐inducible
factor 1α (HIF‐1α) is the inducible subunit of the HIF‐1 transcription factor that regulates …
factor 1α (HIF‐1α) is the inducible subunit of the HIF‐1 transcription factor that regulates …
[HTML][HTML] Induction of hypoxia-inducible factor 1α gene expression by vascular endothelial growth factor
JJP Deudero, C Caramelo, MC Castellanos… - Journal of Biological …, 2008 - ASBMB
Transcriptional regulation of vascular endothelial growth factor (VEGF) is critically
dependent on hypoxia-inducible factor 1 (HIF-1). However, not only hypoxia, but selected …
dependent on hypoxia-inducible factor 1 (HIF-1). However, not only hypoxia, but selected …
Vascular Endothelial Growth Factor Gene Expression in Colon Cancer Cells Exposed to Prostaglandin E2 Is Mediated by Hypoxia-inducible Factor 1
R Fukuda, B Kelly, GL Semenza - Cancer research, 2003 - AACR
Abstract Prostaglandin E2 (PGE2) has been implicated as an inducer of angiogenesis in
human colon cancer. Here, we demonstrate that PGE2 exposure induces the expression of …
human colon cancer. Here, we demonstrate that PGE2 exposure induces the expression of …