Cathepsin-D is an independent marker of poor prognosis in human breast cancer. We
previously showed that human wild-type cathepsin-D, as well as its mutated form devoid of …

Overexpression of cathepsin-D in primary breast cancer has been associated with rapid
development of clinical metastasis. To investigate the role of this protease in breast cancer …

The lysosomal aspartic protease cathepsin D (cath-D) is overexpressed and hyper-secreted
by epithelial breast cancer cells. This protease is an independent marker of poor prognosis …

Recent murine studies have demonstrated that tumor‐associated macrophages in the tumor
microenvironment are a key source of the pro‐tumorigenic cysteine protease, cathepsin S …

The aspartyl-protease cathepsin D (cath-D) is overexpressed and hypersecreted by
epithelial breast cancer cells and stimulates their proliferation. As tumor epithelial–fibroblast …

A short review of the literature first confirms the clinical value of cathepsin D as a prognostic
marker in breast cancer, when using well standardized assays. We then summarize results …

Cathepsin D is an acidic lysosomal protease present in all cells. In estrogen receptor
positive and negative breast cancer cell lines, the mRNA coding for pro-cathepsin D is …

Cathepsin D is an acidic lysosomal protease present in all cells. In breast cancer cells, pro-
cathepsin D expression and secretion are markedly increased and its processing is altered …

Cathepsin D (cath-D) is an aspartyl lysosomal protease expressed in all tissues. Most
metastatic breast cancer cell lines, unlike normal cells, secrete high levels of pro-cath-D …

Cathepsin D (cath‐D) overexpression in breast cancer cells is associated with increased risk
of metastasis in patients according to several clinical studies. No alterations of pro‐cath‐D …