In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutic
agents in the treatment of pain, inflammation and fever. They may also have a role in the …

Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved
by the FDA for the treatment of various forms of arthritis and the management of acute or …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Abstract Cyclooxygenase-2 (COX-2) is an important cellular target for both therapy and/or
prevention of inflammatory disorders and cancer. The advent of selective COX-2 inhibitors …

Background An increasing number of reports is challenging the notion that the antitumor
potential of the selective COX-2 inhibitor celecoxib (Celebrex®) is mediated primarily via the …

Background and Objectives: It is generally accepted that inflammatory cells found in the
tumor microenvironment are involved in the neoplastic process, promoting cell proliferation …

For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty
acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

Cyclooxygenase-2 (COX-2) overexpression is seen in many malignancies including lung
cancer. In non-small cell lung cancer (NSCLC), COX-2 is overexpressed in most …